Results 231 to 240 of about 698,716 (345)

Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts

open access: yesEuropean Journal of Heart Failure, EarlyView.
Markers of progression to heart failure (HF). Gal‐4, galectin‐4; GDF‐15, growth differentiation factor 15; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; ST2, suppression of tumorigenicity‐2. ABSTRACT Aims Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart ...
Anna Dieden   +23 more
wiley   +1 more source

Practical management of repeated life‐threatening status epilepticus in Alternating Hemiplegia of Childhood: Case report and literature review

open access: yesEpileptic Disorders, EarlyView.
Abstract Background Alternating Hemiplegia of Childhood (AHC) is a severe channelopathy that manifests before 18 months of age, primarily caused by pathogenic variants in the ATP1A3 gene. It is characterized by recurrent and disabling episodes of plegia, dystonia, dysautonomia, along with chronic neurological features and cardiac arrhythmias. About 50%
Ramona Cordani   +8 more
wiley   +1 more source

Seminars in epileptology: How to diagnose status epilepticus in adults and children

open access: yesEpileptic Disorders, EarlyView.
Abstract Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation and mechanisms leading to metabolic and inflammatory derangements with increased risk of brain damage, alterations of neural networks, and potentially life‐threatening systemic complications ...
M. Leitinger   +12 more
wiley   +1 more source

ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia

open access: yesEpileptic Disorders, EarlyView.
Abstract The ILAE Neuroimaging Task Force aims to publish educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Here, we describe a case series of three neonates with focal cortical dysplasia (FCD)‐related drug‐resistant epilepsy who underwent surgical intervention. The purpose
Nathan T. Cohen   +18 more
wiley   +1 more source

Lateralizing value of ictal head turning: A systematic review and meta‐analysis

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective To elucidate the lateralizing value of ictal head turning in focal epilepsy and provide guidance for interpreting ictal semiology within the framework of presurgical evaluation. Methods We conducted a systematic review of ictal head turning. We included studies reporting ictal head turning (versive, nonversive, and gyration) captured
Melita Cacic Hribljan   +2 more
wiley   +1 more source

Neonatal seizures: Advances in diagnosis and management

open access: yesEpilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz   +2 more
wiley   +1 more source

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

open access: yesExploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding   +9 more
wiley   +1 more source

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