Results 41 to 50 of about 5,122,361 (303)

Neonatal Intensive Care

Curationis, 1981
THE events of the third trimester of pregnancy labour, delivery and the newborn period undoubtedly influence the whole of one’s life. Old age excluded, the highest mortality rate occurs in the perinatal period.
Lutz Wille, Michael Obladen, Herbert E. Ulmer   +2 more
openaire   +3 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Association between nurse staffing levels and rotavirus infection in neonatal intensive care units: A retrospective observational study

, 2023
Objectives: To explore the relationship between nurse staffing levels and rotavirus infection in neonatal intensive care units. Research methodology: This study adopted a retrospective observational design with data from the Health Insurance Review and ...
Chul-Gyu Kim, Ji-Soo Kim, Kyun-Seop Bae
core   +1 more source

Improving neonatal health in Nepal: Major challenges to achieving millennium development goal 4 [PDF]

, 2013
Background: Globally, more than 40% of all under-five child deaths occur during the neonatal period. Neonatal mortality in Nepal is 33 per 1,000 live births, eight times that of developed regions.
Joshi, R., van Teijlingen, Edwin, Sharma, Sheetal   +2 more
core   +5 more sources

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Pilot study of an instrument to measure attitudes to palliative care practice in neonatal intensive care nursing

, 2007
This paper reports the processes involved in the pilot testing of an instrument – The Neonatal Palliative Care Attitude Scale (NiPCAS). This instrument was developed to explore a context of nursing practice about which little is known – attitudes to ...
Victoria J. Kain, Kain, Victoria J., Kain, VJ   +2 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Extubation failure in very preterm infants: associations with respiratory outcomes in a nine-year cohort study

BMC Pediatrics
Background Extubation failure is a common event in very preterm infants and has been associated with adverse respiratory and clinical outcomes. However, it remains unclear whether extubation failure independently contributes to subsequent morbidity or ...
Kamal Ali, Talal Aljarbou, Saleh Algarni, Saad Alshareedah, Abadi Ghazwani, Naif Alotaibi, Maather Almutairi, Moudhi Alhumaidi, Nouf Alayyar, Mohammed AImahdi, Musab Alshareef, Ahmed Alwatban, Mohamed Khawaji, Abdulaziz Homedi, Saif Alsaif   +14 more
doaj   +1 more source

Real‐Time Holographic Feedback via Mixed Reality Sensorized Laryngoscope Training System Enhances Pediatric Intubation Training

Advanced Robotics Research, EarlyView.
We proposed a Mixed Reality Sensorized Laryngoscope Training System to provide real‐time holographic torque feedback during pediatric endotracheal intubation simulation. Visualization formats are evaluated to reduce tracking error and visual demand.
Jiaqi Li, Ryman Hashem, Ningzhe Hou, Perla Maiolino, Louis Halamek, Liang He   +5 more
wiley   +1 more source