Results 161 to 170 of about 7,511,780 (403)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water for guidance of volume resuscitation to avoid acute kidney injury during shock therapy

Renal Replacement Therapy
Background/objectives Shock and accompanying acute kidney injury (AKI) as a frequent complication is a well-known cause of morbidity and mortality worldwide.
Sereina Roffler, Hannah Büchler-Fehlberg, Anna Dietz, Rita Achermann, Markus Aschwanden, Daniel Staub, Caroline Kiss, Michael Dickenmann, Caroline Eva Gebhard, Alexa Hollinger, Martin Siegemund   +10 more
doaj   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Effects of HALP Score, C-Reactive Protein/Albumin Ratio, and Platelet/Lymphocyte Ratio on Predicting Mortality in Geriatric Patients in the Respiratory Intensive Care Unit

Clinical Interventions in Aging
Kamuran Uluç,1 Esra Akkütük Öngel,2 Şükran Merve Çolakoğlu,2 Nazan Köylü İlkaya,2 Özkan Devran,2 Ahmet Oğuzhan Küçük,3 Hatice Kutbay Özçelik2 1Department of Critical Care Medicine, University of Health Sciences ...
Uluç K, Akkütük Öngel E, Çolakoğlu ŞM, Köylü İlkaya N, Devran Ö, Küçük AO, Kutbay Özçelik H   +6 more
doaj  

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Intensive care in Spain

Revista Española de Anestesiología y Reanimación (English Edition), 2020
C.A. Sánchez Pérez, R. Peyró García, Pablo Monedero, F. Barturen, M. Heredia Rodríguez, M Varela Durán, O.M. Padrón Ruiz, V. Torres Pedrós, L. Fernández-Quero Bonilla, F. García-Montoto Pérez, E. Tamayo Gómez, R. González Celdrán, A. Pérez Carbonell, C. López Sánchez, J. Cardona Peretó, R. Cabadas Avión, D. Paz-Martín, C. Soria Gulina, N. Ojeda Betancor, C. Ferrando Ortolá   +19 more
openaire   +6 more sources

ESPEN guideline on clinical nutrition in the intensive care unit.

Clinical Nutrition, 2019
P. Singer, A. Blaser, M. Berger, W. Alhazzani, P. Calder, M. Casaer, M. Hiesmayr, K. Mayer, J. Montejo, C. Pichard, J. Preiser, A. V. van Zanten, Simon J Oczkowski, W. Szczeklik, S. Bischoff   +14 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit

Critical Care Medicine, 2013
J. Barr, Gilles L. Fraser, K. Puntillo, E. Ely, C. Gélinas, Joseph F. Dasta, Judy E. Davidson, John W. Devlin, John P. Kress, Aaron M. Joffe, D. Coursin, Daniel L. Herr, A. Tung, Bryce R. H. Robinson, Dorrie K. Fontaine, Michael A. Ramsay, R. Riker, C. Sessler, B. Pun, Y. Skrobik, Roman Jaeschke   +20 more
semanticscholar   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source