Results 51 to 60 of about 2,458,151 (310)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Expertise and the interpretation of computerized physiological data: implications for the design of computerized monitoring in neonatal intensive care [PDF]

, 2001
This paper presents the outcomes from a cognitive engineering project addressing the design problems of computerized monitoring in neonatal intensive care.
ALBERDI, ALBERDI, ALBERDI, ANDY LYON, AZEVEDO, BARNARD, BOSHUIZEN, CARD, CARROLL, CHASE, CHI, CLAESSEN, COIERA, COIERA, COIERA, CUNNINGHAM, CUNNINGHAM, DEERE, EDWORTHY, EGAN, ELSTEIN, ELSTEIN, ERICSSON, ERICSSON, ERICSSON, ERICSSON, EUGENIO ALBERDI, FELTOVICH, FELTOVICH, GILHOOLY, GILHOOLY, GRAY, GREEN, GREEN, GREMY, HAIMOWITZ, JAN REISS, JIM HUNTER, JOSEPH, JULIE-CLARE BECHER, KEN GILHOOLY, LANDAUER, LARKIN, LARKIN, LEMIEUX, LESGOLD, LESGOLD, LOGIE, LONG, LONG, MCINTOSH, MORGAN, NEIL MCINTOSH, NENOV, NORMAN, PATEL, PATEL, PATEL, PATEL, PATEL, ROBERT LOGIE, SALATIAN, SCHMIDT, SCHMIDT, TABOADA, WICKENS   +65 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements

Annals of Intensive Care, 2020
Background Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is essential.
Konstantinos Bachoumas, Albrice Levrat, Aurélie Le Thuaut, Stéphane Rouleau, Samuel Groyer, Hervé Dupont, Paul Rooze, Nathanael Eisenmann, Timothée Trampont, Julien Bohé, Benjamin Rieu, Jean-Charles Chakarian, Aurélie Godard, Laura Frederici, Stephanie Gélinotte, Aurélie Joret, Pascale Roques, Benoit Painvin, Christophe Leroy, Marcel Benedit, Loic Dopeux, Edouard Soum, Vlad Botoc, Muriel Fartoukh, Marie-Hélène Hausermann, Toufik Kamel, Jean Morin, Roland De Varax, Gaetan Plantefève, Alexandre Herbland, Matthieu Jabaudon, Thibault Duburcq, Christelle Simon, Russell Chabanne, Francis Schneider, Frederique Ganster, Cedric Bruel, Ahmed-Saïd Laggoune, Delphine Bregeaud, Bertrand Souweine, Jean Reignier, Jean-Baptiste Lascarrou   +41 more
doaj   +1 more source

History of British Intensive Care, c. 1950–c. 2000 [PDF]

, 2011
Annotated and edited transcript of a Witness Seminar held on 16 June 2010. Introduction by Professor Sir Ian Gilmore, Royal Liverpool Hospital and University of Liverpool.Annotated and edited transcript of a Witness Seminar held on 16 June 2010 ...
REYNOLDS, LA, TANSEY, EM
core  

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. [PDF]

, 2014
OBJECTIVE: Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. The aim of this consensus is to provide support to the bedside clinician regarding the diagnosis, management and monitoring of shock.
A Babaev, A Bourgoin, A Combes, A Dubin, A Geppert, A Gestel van, A Perel, A Perel, A Rhodes, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, A Vieillard-Baron, AE Jones, AF Connors Jr, Alexandre Mebazaa, AM Schulman, Andrew Rhodes, AP Wheeler, AS Beraud, B Bouhemad, B Lamia, B Vallet, BP Cholley, BR Soller, C Alberti, C Brun-Buisson, C Brun-Buisson, C Brun-Buisson, C Pierrakos, CA Polanczyk, Christoph Hofer, CI Pro, D Annane, D Atkins, D Backer De, D Backer De, D Backer De, D Backer De, D Backer De, D Fagnoul, D LeDoux, Daniel De Backer, DR Holmes Jr, E Kupersztych-Hagege, E Rivers, E Silva, EP Rivers, F Boissier, F Michard, F Michard, F Vallee, G Friedman, G Hernandez, G Lheritier, G Marecaux, G Tachon, GA Wanner, H Flaatten, H Zhang, H Zhang, HB Nguyen, HH Awad, I Jawad, I Salvo, I Werra de, J Bakker, J Bakker, J Creteur, J Maizel, J Mesquida, Jan Bakker, JB Hall, JD Ricard, Jean Louis Teboul, Jean Louis Vincent, JH McGowan, JJ Ronco, JL Teboul, JL Vanoverschelde, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JL Vincent, JP Quenot, JP Revelly, K Bouferrache, L Jacquet, M Antonelli, M Cannesson, M Cecconi, M Cecconi, M Cecconi, M Feissel, M Howell, M Pinsky, MA Hayes, Massimo Antonelli, Maurizio Cecconi, ME Genderen van, ME Genderen van, ME Hands, ME Mikkelsen, MH Weil, MH Weil, MI Monge Garcia, MI Monge Garcia, Michael R. Pinsky, MR Pinsky, MR Shah, NJ Ekbal, O Godje, O Hamzaoui, O Taton, P Asfar, P Asfar, P Vignon, P Wacharasint, PE Marik, PT O’Gara, RA Linton, Richard Beale, RJ Goldberg, RJ Goldberg, Roman Jaeschke, RP Dellinger, RS Hotchkiss, S Harvey, S Heenen, S Magder, S Magder, S Magder, S Magder, S Marque, S Trzeciak, SA Stern, SD Murdoch, SF Nagueh, SG Sakka, SM Cain, SR Ommen, TC Jansen, TC Jansen, TC Jansen, TC Jansen, VS Edul, WH Bickell, WT Linde-Zwirble, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, X Monnet, Y Sakr, Y Sakr   +157 more
core   +5 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source