Results 51 to 60 of about 5,614,983 (259)
Investigation Of Sleep Disorders In Intensive Care Nurses
, 2011 Objective: The aim of this study was to investigate the sleep quality of intensive care nurses. Material and Method: Sixty volunteer intensive care, policlinic and general wards nurses working in Celal Bayar University Hospital were included as three ...
Gülay Ok +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2023 OBJECTIVES: The aim of this study was to gain an increased understanding of the intensive care unit diary and how it affects patients' recovery after intensive care.
Olby, Karin +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2014 Neuroleptic malignant syndrome (NMS) is a rare but life-threatening clinical manifestation induced by neuroleptic medication. Although NMS is regarded as a psychiatric diagnosis, its treatment requires a systematic approach and thus intensive care follow-
Yeşim Beckmann +4 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Intensive Care Management in Pediatric Burn Patients
, 2011 Burn injury is still a leading cause of morbidity and mortality in children. This article aimed to review the current principles of management from initial assessment to early management and intensive care for pediatric burn patients.
Ayşe Ebru Sakallıoğlu Abalı
core
Rational use of intensive care beds in Turkey: Point prevalence survey study
Objective: The limitation or withdrawal of futile treatment is widely accepted in the intensive care and medical ethics literature. However, implementing this in clinical practice is often difficult. The aim of the study is to understand the situation of
Demirag, Kubilay +6 more
core +1 more source
Annals of Intensive Care, 2020 Background Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is essential.
Konstantinos Bachoumas +41 more
doaj +1 more source