Results 161 to 170 of about 1,998,001 (374)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Correlation Between Immune-Inflammatory Biomarkers During Pregnancy and Postpartum and Adverse Outcomes of Preeclampsia: A Longitudinal Retrospective Analysis

Journal of Inflammation Research
Xinke Guo,1,* Weimin Tao,1,* Qingsong Zhao,2 Cuicui Qu,1 Xiang Li,1 Xiaoru Sun,1 Zhendong Xu1,2 1Department of Intensive Care Unit, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and ...
Guo X, Tao W, Zhao Q, Qu C, Li X, Sun X, Xu Z   +6 more
doaj  

Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study

Journal of Anesthesia, Analgesia and Critical Care
Background Sepsis-3 emphasizes the recognition of sepsis-induced cellular metabolic abnormalities, and utilizes serum lactate level as a biomarker of cellular metabolic abnormalities. Magnesium plays an important role as a cofactor in glucose metabolism,
Ken Tonai, Shinshu Katayama, Kansuke Koyama, Hisashi Imahase, Shin Nunomiya   +4 more
doaj   +1 more source

Cocaine use in trauma patients admitted to intensive care medicine. clinical and epidemiological characterization [PDF]

, 2015
Federico Verga, Antonio Pascale, Joan Gil, Adriana Ayres de Oliveira França, Ignacio Álvez, Estefanía Otálvaro Echavarría, Homero Bagnulo   +6 more
openalex   +1 more source

Narrative Medicine In Intensive Care

Anesthesia & Clinical Care, 2019
Narrative Medicine fortifies clinical practice with the narrative competence to interpret the stories of illness. The histories of illness pass through a process of listening and empathic understanding aimed at the therapeutic objective. Storytelling is an inherent behavior in humans. This becomes more important in intensive care where technology often
E. Primerano, D. Alampi
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

[Perioperative analgesia with nonopioid analgesics : Joint interdisciplinary consensus-based recommendations of the German Pain Society, the German Society of Anaesthesiology and Intensive Care Medicine and the German Society of Surgery].

, 2021
Ulrike M. Stamer, Joachim Erlenwein, Stephan M. Freys, Thomas Stammschulte, Dirk O. Stichtenoth, Stefan Wirz   +5 more
openalex   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Data mining predictive models for pervasive intelligent decision support in intensive care medicine [PDF]

, 2012
The introduction of an Intelligent Decision Support System (IDSS) in a critical area like the Intensive Medicine is a complex and difficult process.
Pinto, Filipe, Portela, Filipe, Santos, Manuel Filipe   +2 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source