Results 111 to 120 of about 2,158,632 (410)

Quantitative Pupillometry in the Intensive Care Unit

Journal of Intensive Care Medicine, 2019
Quantitative pupillometry provides a noninvasive and objective assessment within the neurological examination. This review details the physiology of the pupillary light response, the clinical significance of changes in pupillary reactivity, and the ...
M. Bower, A. Sweidan, Jordan C. Xu, Sara Stern-Neze, Wengui Yu, Leonid I. Groysman   +5 more
semanticscholar   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

Molecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch, Sara Sánchez‐Serra, Marta Rosàs‐Lapeña, Nicolás Costa‐Fraga, Judit Besalú‐Velázquez, Janet Illa‐Bernadí, Silvia Mateo‐Lozano, Florencia Cidre‐Aranaz, Thomas G.P. Grünewald, Ángel Díaz‐Lagares, Roser Lopez‐Alemany, Òscar M. Tirado   +11 more
wiley   +1 more source

UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease

Applied Bionics and Biomechanics
Background. Moyamoya disease (MMD) leads to nerve injury. Exosomes are touted as bio-shuttles for the delivery of distinct biomolecules inside the cells. Recently, UCH-L1 was shown to play a vital role in nerve injury.
Minghua Xu, Xiaomin Zhao, Jiang Zhao, Zhisheng Tan, Chengshi Zhang, Yun Huang, Huiping Zhong, Meifeng Guo, Chen Zhang, Ping Ye, Wentao Zheng   +10 more
doaj   +1 more source

Optimizing Medical Treatment for Sepsis in Intensive Care: from Reinforcement Learning to Pre-Trial Evaluation [PDF]

arXiv, 2020
Our aim is to establish a framework where reinforcement learning (RL) of optimizing interventions retrospectively allows us a regulatory compliant pathway to prospective clinical testing of the learned policies in a clinical deployment. We focus on infections in intensive care units which are one of the major causes of death and difficult to treat ...
arxiv  

Telemedicine coverage for post-operative ICU patients. [PDF]

, 2017
Introduction There is an increased demand for intensive care unit (ICU) beds. We sought to determine if we could create a safe surge capacity model to increase ICU capacity by treating ICU patients in the post-anaesthesia care unit (PACU) utilizing a ...
Collins, Tara Ann, Holena, Daniel N., Kohl, Benjamin A., Pisa, Michael A., Reilly, Patrick M., Robertson, Matthew P., Sicoutris, Corinna P.   +6 more
core   +1 more source

Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life [PDF]

, 2017
The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined.
Boustani, Malaz, Gao, Sujuan, Khan, Babar, Khan, Sikandar, Lasiter, Sue, Mosher, Chris, Perkins, Anthony J., Wang, Sophia   +7 more
core   +1 more source

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Insights from patients screened but not randomised in the HYPERION trial

Annals of Intensive Care, 2021
Background Few data are available about outcomes of patients screened for, but not enrolled in, randomised clinical trials. Methods We retrospectively reviewed patients who had non-inclusion criteria for the HYPERION trial comparing 33 °C to 37 °C in ...
J. B. Lascarrou, Gregoire Muller, Jean-Pierre Quenot, Nicolas Massart, Mickael Landais, Pierre Asfar, Jean-Pierre Frat, Jean-Charles Chakarian, Michel Sirodot, Bruno Francois, Guillaume Grillet, Sylvie Vimeux, Arnaud Delahaye, Stéphane Legriel, Didier Thevenin, Jean Reignier, Gwenhael Colin, for the AfterROSC Network   +17 more
doaj   +1 more source

An Interpretable Intensive Care Unit Mortality Risk Calculator [PDF]

arXiv, 2021
Mortality risk is a major concern to patients have just been discharged from the intensive care unit (ICU). Many studies have been directed to construct machine learning models to predict such risk. Although these models are highly accurate, they are less amenable to interpretation and clinicians are typically unable to gain further insights into the ...
arxiv  

Ethics in the Intensive Care Unit

Tuberculosis and Respiratory Diseases, 2015
The intensive care unit (ICU) is the most common place to die. Also, ethical conflicts among stakeholders occur frequently in the ICU. Thus, ICU clinicians should be competent in all aspects for ethical decision-making. Major sources of conflicts are behavioral issues, such as verbal abuse or poor communication between physicians and nurses, and end-of-
Ju-Ock Kim, Jae Young Moon
openaire   +3 more sources