Results 181 to 190 of about 113,262 (301)

A Physiologically Based Modeling Approach to Evaluate Intravenous Levetiracetam Dosing in Term and Preterm Neonates

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Seizures are the most common neurologic emergency in neonates and are associated with significant morbidity and mortality. Current first‐line pharmacotherapy, phenobarbital, is associated with serious adverse effects, including impairment of the developing brain.
Alexis Johnson   +4 more
wiley   +1 more source

From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract We previously developed a population pharmacokinetic (PopPK) model for meropenem in pediatric intensive care unit patients accounting for effect of body size, maturation, and kidney function on clearance. This study aimed to extrapolate meropenem exposure to neonates and young infants using the pediatric PopPK model and to validate the ...
Ronaldo Morales Junior   +4 more
wiley   +1 more source

Diagnosis of Spontaneous Massive Fetomaternal Hemorrhage: A Case Report and Literature Review

open access: yesJournal of Clinical Ultrasound, EarlyView.
Fetomaternal hemorrhage (FMH) is the passage of fetal blood through the circulatory system of the mother either before or during delivery, and it is rarely diagnosed prenatally. This paper aims to present a comprehensive review of the literature allowing us to offer comprehensive insights into the diagnosis and management of FMH.
Martina Derme   +11 more
wiley   +1 more source

Prominent Chiari Network as a Cause of Cyanosis in Infants: A Case Report and Implications for Pediatric Cardiology Practice

open access: yesJournal of Clinical Ultrasound, EarlyView.
A prominent Chiari network can cause cyanosis in infants by inducing a positional right‐to‐left atrial shunt. Accurate diagnosis enabled conservative management, delaying surgery until optimal conditions. This case emphasizes the importance of echocardiographic evaluation in differentiating cyanosis mechanisms to guide appropriate treatment in ...
Carmen Rodríguez‐Barrios   +2 more
wiley   +1 more source

Assessing the Utility of Targeted Neonatal Echocardiography for Congenital Heart Disease Detection: Retrospective Cohort Analysis

open access: yesJournal of Clinical Ultrasound, EarlyView.
Targeted neonatal echocardiography showed good agreement with cardiology‐performed studies in detecting significant congenital heart disease. Most missed lesions were minor, highlighting both the value of TNE in neonatal care and the need for continued training to optimize diagnostic accuracy.
Eyad Bitar   +8 more
wiley   +1 more source

Do the early social environment and persistent peripartum depressive symptoms shape toddlers' expressive language?

open access: yesJCPP Advances, EarlyView.
Abstract Background Extensive research suggests that peripartum depression is a risk factor for children's early language development. Yet, previous research on this association shows mixed results, often lacking information on the persistence of depression and the social context.
Hsing‐Fen Tu   +3 more
wiley   +1 more source

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