Results 121 to 130 of about 133,727 (305)

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Increasing Resistance to Ceftriaxone in Pediatric Intensive Care Units

Journal of Rawalpindi Medical College, 2019
Background: Cephalosporins are one of the most widely and generously used antibiotics in treatment of infections in patients admitted to the hospital. However due to their over use, resistance to 3rd generation cephalosporins like ceftriaxone is becoming
Chaudhary Ehtsham Azmat, Abdul Basit Shah Vardag, Ahmed Moosa Kazi, Muhammed Ammad- Ud-Din, Faraz Iftikhar, Hassan Liaqat, Nadeem Ikram   +6 more
doaj  

Pediatric intensive care unit admissions network—rationale, framework and method of operation of a nationwide collaborative pediatric intensive care research network in Germany

Frontiers in Pediatrics
The Pediatric Intensive Care Unit Admissions (PIA) network aims to establish a nationwide database in Germany to gather epidemiological, clinical, and outcome data on pediatric critical illness.
Nora Bruns, Nora Bruns, Christian Dohna-Schwake, Christian Dohna-Schwake, Martin Olivieri, Michael S. Urschitz, Susanne Blomenkamp, Clara Frosch, Clara Frosch, Victoria Lieftüchter, Markos K. Tomidis Chatzimanouil, Florian Hoffmann, Sebastian Brenner   +12 more
doaj   +1 more source

Neonatal intensive care and its application in Malta [PDF]

, 1990
The introduction of neonatal techniques has proved vital in the reduction of infant mortality rates. This article describes 4 important and basic techniques in neonatal intensive care; ventilation, nutrition, monitoring and cerebral assessment.
Azzopardi, Denis
core  

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

PERANCANGAN APLIKASI ELECTRONIC MEDICAL RECORD (EMR) PADA INSTALASI RAWAT INAP BERBASIS WEB [PDF]

, 2011
Pelayanan medik dewasa ini membutuhkan sistem yang lebih efektif dan efisien, baik dalam penggunaan waktu, tenaga maupun sarana. Dalam pengelolaan rekam medik, kenyataan masih umumnya penggunaan rekam medik manual yang dinilai tak lagi andal menangani ...
Handoyo, Eko, Muttaqin, Moh, Sofwan, Aghus   +2 more
core