Results 221 to 230 of about 54,455 (304)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Extended NICUs or specialized pediatric networks? The need to reinforce centralized, multidisciplinary care - a comment on Decembrino et al. [PDF]

Ital J Pediatr
Brisca G, Ingelmo PM, Camporesi A, Di Nardo M, Dato A, Ricci Z, Bussolin L, Conti G, Tesoro S, Minardi C, Marinosci GZ, Wolfler A, Moscatelli A, Italian Society of Neonatal and Pediatric Anesthesia and Intensive Care (SARNePI).   +13 more
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Implementation mapping to develop strategies for skin-to-skin care in the pediatric cardiac intensive care unit: planning for a hybrid trial. [PDF]

Front Pediatr
Bettencourt A, Whittaker J, Nag D, Kellom KS, Brennan C, Herrup EA, Demianczyk A, Lisanti AJ.   +7 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Risk factors for acute kidney injury in pediatric intensive care units: a systematic review and meta-analysis. [PDF]

BMC Pediatr
Li R, Yang Q.
europepmc   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Clinical outcomes and associated factors in pediatric patients undergoing tracheostomy in a public intensive care unit. [PDF]

Crit Care Sci
Almeida IS, Serra LSM, Praia CFC, Serafim AP.   +3 more
europepmc   +1 more source

Impact of Different Pre‐Dilution Methods on Routine Blood Test Results: A Study With Sysmex XN‐1000

Journal of Clinical Laboratory Analysis, EarlyView.
The wet wipe method demonstrated excellent consistency with automated injection across all five parameters and is recommended as the preferred technique when sample volume is limited. ABSTRACT Objectives To compare three manual pre‐dilution procedures with the automated undiluted mode on the Sysmex XN‐1000 analyzer and to identify an optimal standard ...
Lingsong Wu, Mengzhe Qin, Zhe Xing, Fengli Jiang, Sien Zhan, Jintian Hu   +5 more
wiley   +1 more source

Understanding the Influence of the Work Environment on Family-Centered Care Among Nurses in Neonatal Intensive Care Units. [PDF]

Nurs Res Pract
Jada'a M, Ayed A.
europepmc   +1 more source