Results 101 to 110 of about 1,631,497 (414)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

NURSING ATTENTION DEMANDS AT A NEONATAL, PEDIATRIC AND GENERAL INTENSIVE CARE UNIT

open access: yesCogitare Enfermagem, 2015
Descriptive and quantitative study to identify intensive nursing attention demands and the efforts these professionals make to cope with these demands.
Danilo Marcelo Araujo dos Santos   +4 more
doaj   +1 more source

False arrhythmia alarm reduction in the intensive care unit [PDF]

open access: yes, 2017
Research has shown that false alarms constitute more than 80% of the alarms triggered in the intensive care unit (ICU). The high false arrhythmia alarm rate has severe implications such as disruption of patient care, caregiver alarm fatigue, and desensitization from clinical staff to real life-threatening alarms. A method to reduce the false alarm rate
arxiv   +1 more source

SARS in the intensive care unit [PDF]

open access: yesCurrent Infectious Disease Reports, 2004
Approximately 20% of patients with severe acute respiratory syndrome (SARS) develop respiratory failure that requires admission to an intensive care unit (ICU). Old age, comorbidity, and elevated lactate dehydrogenase on hospital admission are associated with increased risk for ICU admission.
Gavin M. Joynt, H Y Yap
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Abdominal physical examinations in early stages benefit critically ill patients without primary gastrointestinal diseases: a retrospective cohort study

open access: yesFrontiers in Medicine
BackgroundGastrointestinal (GI) function is critical for patients in intensive care units (ICUs). Whether and how much critically ill patients without GI primary diseases benefit from abdominal physical examinations remains unknown.
Xiao Cui   +6 more
doaj   +1 more source

Does early tracheostomy affect the duration of mechanical ventilation in patients with severe traumatic head injuries?

open access: yesThe Egyptian Journal of Otolaryngology, 2018
Background and purpose Tracheostomy is a surgical procedure performed frequently in intensive care units (ICUs). Prolonged mechanical ventilation (MV) is the main indication for tracheostomy in ICUs.
M. M. Roushdy   +2 more
doaj   +1 more source

Classifying the evolution of COVID-19 severity on patients with combined dynamic Bayesian networks and neural networks [PDF]

open access: yesarXiv, 2023
When we face patients arriving to a hospital suffering from the effects of some illness, one of the main problems we can encounter is evaluating whether or not said patients are going to require intensive care in the near future. This intensive care requires allotting valuable and scarce resources, and knowing beforehand the severity of a patients ...
arxiv  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

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