Results 101 to 110 of about 929,596 (365)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Sedation in intensive care units [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2018
Critically ill patients during the treatment in the intensive care units (ICU) are exposed to various interventions and stressors from the environment that represent a significant source of discomfort.
Veličković Jelena, Palibrk Ivan
doaj  

The validity and reliability of the portuguese versions of three tools used to diagnose delirium in critically ill patients

Clinics, 2011
OBJECTIVES: The objectives of this study are to compare the sensitivity and specificity of three diagnostic tools for delirium (the Intensive Care Delirium Screening Checklist, the Confusion Assessment Method for Intensive Care Units and the Confusion ...
Dimitri Gusmao-Flores, Jorge Ibrain Figueira Salluh, Felipe Dal-Pizzol, Cristiane Ritter, Cristiane Damiani Tomasi, Marco Antônio Sales Dantas de Lima, Lauro Reis Santana, Rita Márcia Pacheco Lins, Patrícia Pimenta Lemos, Gisele Vasconcelos Serpa, Jenisson Oliveira, Ricardo Ávila Chalhub, Melissa Tassano Pitrowsky, Acioly L.T Lacerda, Karestan C Koenen, Lucas C Quarantini   +15 more
doaj   +1 more source

Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002–2010)

Intensive Care Medicine, 2014
PurposeTo analyze trends in incidence and mortality of candidemia in intensive care units (ICUs) vs. non-ICU hospitalized patients and to determine risk factors for infection by specific species and for death.MethodsActive hospital-based surveillance ...
O. Lortholary, C. Renaudat, K. Sitbon, Y. Madec, Lise Denoeud-Ndam, M. Wolff, A. Fontanet, S. Bretagne, F. Dromer   +8 more
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Advanced Heart Failure: Therapeutic Options and Challenges in the Evolving Field of Left Ventricular Assist Devices

Journal of Cardiovascular Development and Disease
Heart Failure is a chronic and progressively deteriorating syndrome that has reached epidemic proportions worldwide. Improved outcomes have been achieved with novel drugs and devices.
Michael Antonopoulos, Michael J. Bonios, Stavros Dimopoulos, Evangelos Leontiadis, Aggeliki Gouziouta, Nektarios Kogerakis, Antigone Koliopoulou, Dimitris Elaiopoulos, Ioannis Vlahodimitris, Maria Chronaki, Themistocles Chamogeorgakis, Stavros G. Drakos, Stamatis Adamopoulos   +12 more
doaj   +1 more source

Hospital mortality of adults admitted to Intensive Care Units in hospitals with and without Intermediate Care Units: a multicentre European cohort study

Critical Care, 2014
IntroductionThe aim of the study was to assess whether adults admitted to hospitals with both Intensive Care Units (ICU) and Intermediate Care Units (IMCU) have lower in-hospital mortality than those admitted to ICUs without an IMCU.MethodsAn ...
M. Capuzzo, C. Volta, Tania Tassinati, R. Moreno, A. Valentin, B. Guidet, G. Iapichino, Claude D Martin, T. Perneger, C. Combescure, A. Poncet, A. Rhodes   +11 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey, Ahmad A. Toubasi, Jiacheng Wang, Habeeb F. Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A. Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato   +17 more
wiley   +1 more source