Results 51 to 60 of about 1,130,227 (299)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Multiple finances, margins of foreign direct investment and aggregate industry productivity [PDF]

Financial Theory and Practice, 2012
Based on a heterogeneous firm set-up, we model firms’ access to the internal capital market, bank finance as well as bond finance and investigate how firms’ adjustment among multiple sources of finance affects their performance in foreign direct ...
Jiarui Zhang, Lei Hou
doaj  

THE INTENSIVE MARGIN PUZZLE AND LABOR MARKET ADJUSTMENT COSTS [PDF]

Macroeconomic Dynamics, 2015
This paper documents a puzzling fact, namely that there is a significant negative relation between employment protection legislation and the usage of the intensive margin of labor market adjustments. I make use of a real business cycle model and introduce search and matching frictions as well as adjustment costs along the extensive and the intensive ...
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cycling on the extensive and intensive margin: The role of paths and prices [PDF]

Transportation Research Part A: Policy and Practice, 2017
Abstract Drawing on a panel of German survey data spanning 1999–2013, this paper identifies the correlates of non-recreational bicycling, focusing specifically on the roles of bicycle paths and fuel prices. Our approach conceptualizes ridership as a two-stage decision process comprising the discrete choice of whether to use the bike (i.e.
Frondel, Manuel, Vance, Colin
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The extensive and intensive effects of Vietnam’s technical measures on agricultural imports

Cogent Economics & Finance
Technical measures, particularly Sanitary and Phytosanitary measures (SPS) and Technical barriers to trade (TBT) can affect to firms’ market entry and the volume of trade.
Bich Ngoc Nguyen
doaj   +1 more source

The Impact of Trade Facilitation on the Extensive and Intensive Margins of Trade: An Application for Developing Countries

East Asian Economic Review, 2012
Previous literature has looked merely into the effect of trade facilitation on aggregate trade, or analyzed trade growth using the extensive and intensive margins.
Hyo-young Lee , Chong-Sup Kim
doaj   +1 more source

Effectiveness of Multifunctional Margins in Insect Biodiversity Enhancement and RTE Species Conservation in Intensive Agricultural Landscapes

Agronomy, 2021
Starting in the 1950s, agricultural production has been remarkably intensified, resulting in modern management systems where a severe increase in field size led to an elimination of edges and other ecologically valuable structural elements. The resulting
Fernando Santa, Luis Oscar Aguado, José Vicente Falcó-Garí, Ricardo Jiménez-Peydró, Michael Schade, Vasileios Vasileiadis, Luis Miranda-Barroso, Francisco Javier Peris-Felipo   +7 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source