Results 171 to 180 of about 8,514,767 (300)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Intensive Treatment of Chronic Pain and PTSD: The PATRIOT Program. [PDF]

Behav Sci (Basel)
Otis JD, Comer JS, Keane TM, Checko Scioli E, Pincus DB.   +4 more
europepmc   +1 more source

Effects of Sexual Orientation on Spiritual Psychotherapy for Inpatient, Residential & Intensive Treatment. [PDF]

Psychiatr Res Clin Pract, 2022
Schuttenberg EM, Johnston AM, Drury MJ, Sneider JT, Silveri MM, Rosmarin DH.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Exploration of factors associated with eGFR slope improvement before and after intensive treatment of patients with diabetic nephropathy at high risk of disease progression: a retrospective cohort study. [PDF]

J Rural Med
Kiku M, Sako S, Inada T, Hayashi S, Terada M, Shibata K, Shima KR.   +6 more
europepmc   +1 more source

A model-based approach for a practical dosing strategy for the short, intensive treatment regimen for paediatric tuberculous meningitis. [PDF]

Front Pharmacol, 2023
Wasmann RE, Masini T, Viney K, Verkuijl S, Brands A, Hesseling AC, McIlleron H, Denti P, Dooley KE.   +8 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Examining treatment outcomes for military service members in an intensive treatment program for posttraumatic stress disorder. [PDF]

Mil Psychol
Murphy JW, Smith DL, Hiner K, Zolper J, Pridgen S, Schroedter B, Held P.   +6 more
europepmc   +1 more source

Comparison of a Telehealth-Based Intensive Treatment Program with a Rewarding App vs. On-Site Care for Youth with Obesity: A Historical Cohort Study. [PDF]

Children (Basel), 2023
Sela Peremen K, Maor S, Yaniv A, Aloni I, Ziv-Baran T, Dubnov-Raz G.   +5 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source