Results 51 to 60 of about 8,514,767 (300)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Explaining anomalous responses to treatment in the Intensive Care Unit [PDF]

, 2009
The Intensive Care Unit (ICU) provides treatment to critically ill patients. When a patient does not respond as expected to such treatment it can be challenging for clinicians, especially junior clinicians, as they may not have the relevant experience to
Hughes, M., Malcolm Sim, Kinsella, J., Lyndsay Donaldson, Malcolm Booth, Donaldson, L., Moss, Laura, Sim, M., Laura Moss, Malcolm Daniel, Daniel, M., Martin Hughes, Gilhooly, C., Booth, M., Charlotte Gilhooly, Sleeman, D., Derek Sleeman, John Kinsella   +17 more
core   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Identifying Priorities in Intensive Care : a description of a system for collecting intensive care data, an analysis of the data collected, a critique of aspects of severity scoring systems used to compare intensive care outcome, identification of priorities in intensive care and proposals to improve outcome for intensive care patients. [PDF]

, 1999
MDThis thesis reviews the requirements for intensive care audit data and describes the development of ICARUS (Intensive Care Audit and Resource Utilisation System), a system to collect and analyse intensive care audit information.
Goldhill, David Raymond
core   +4 more sources

Is Spinal Analgesia or Anesthesia Safe After Labor Epidural Analgesia? Reporting Two Cases of High Neuraxial Block and Mini-Review of the Literature

Reports
Background and Clinical significance: Single-shot spinal anesthesia for intrapartum Cesarean section has recently been incriminated in carrying a high risk of high neuraxial block (HNB) occurrence in parturients receiving labor epidural analgesia. The so-
Arsen Uvelin, Marijana Cavrić-Dragičević, Borislava Pujić, Lidija Jovanović, Teodora Tubić, Radmila Popović   +5 more
doaj   +1 more source

Post-treatment predictors of follow-up status for obsessive-compulsive disorder treated with concentrated exposure therapy

Cogent Psychology, 2018
Recommended psychological treatment for obsessive-compulsive disorder (OCD) is cognitive behavioral therapy (CBT) including exposure with response prevention (ERP).
Silje Elisabeth Hasmo Holm, Bjarne Hansen, Gerd Kvale, Thomas Eilertsen, Torun Grøtte, Stian Solem   +5 more
doaj   +1 more source

Do morally injurious experiences and index events negatively impact intensive PTSD treatment outcomes among combat veterans?

European Journal of Psychotraumatology, 2021
Background: It has been suggested that current frontline posttraumatic stress disorder (PTSD) treatments are not effective for the treatment of moral injury and that individuals who have experienced morally injurious events may respond differently to ...
Philip Held, Brian J. Klassen, Victoria L. Steigerwald, Dale L. Smith, Karyna Bravo, David C. Rozek, Rebecca Van Horn, Alyson Zalta   +7 more
doaj   +1 more source

The Concept of Ethics in the Intensive Care

, 2010
The concept of ethics in the intensive care unit has developed in the last 50 years along with the advancements and regulations in this area of medicine.
Kutay Alpir
core   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source