Results 231 to 240 of about 1,788,230 (280)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hair stress hormones in individuals with a recent suicide attempt experiencing a depressive episode. [PDF]

Neurobiol Stress
Colic L, Seiffert AK, Bahlmann L, Zerekidze A, Walther J, McClain L, Besteher B, Pereira F, Abbar M, Walter M, Jollant F, Wagner G.   +11 more
europepmc   +1 more source

Burnout, Belonging, and Mental Well-Being: Predictors of Turnover Intent Among Local Public Health Professionals. [PDF]

J Public Health Manag Pract
McCall TC, Perkins K, Alford AA.
europepmc   +1 more source

To Signal or Not to Signal? A Non-cooperative Game-Theoretic Approach to Discretionary Communication Between Road Users. [PDF]

SN Comput Sci
Bitar I, Solernou Crusat A, Romano R, Watling D.   +3 more
europepmc   +1 more source

Clinicopathologic Characteristics, Treatment Outcomes, and Survival in Thymic Neuroendocrine Neoplasms (t-NEN): A 25-Year Single-Center Experience. [PDF]

Cancers (Basel)
Piórek A, Płużański A, Kowalski DM, Krzakowski M.   +3 more
europepmc   +1 more source

Well-Being Leadership Training to Reduce Clinician Burnout in a Metropolitan Community Health System. [PDF]

Healthcare (Basel)
James TT, Nayak AC, Houff AM, Kantamneni PC, Li HF, Scanlan JM, Chun LLMW.   +6 more
europepmc   +1 more source