Results 61 to 70 of about 41,579 (241)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Research on Co-Interactive Model Based on Knowledge Graph for Intent Detection and Slot Filling

Applied Sciences
Intent detection and slot filling tasks share common semantic features and are interdependent. The abundance of professional terminology in specific domains, which poses difficulties for entity recognition, subsequently impacts the performance of intent ...
Wenwen Zhang, Yanfang Gao, Zifan Xu, Lin Wang, Shengxu Ji, Xiaohui Zhang, Guanyu Yuan   +6 more
doaj   +1 more source

A Query Understanding Framework for Earth Data Discovery

Applied Sciences, 2020
One longstanding complication with Earth data discovery involves understanding a user’s search intent from the input query. Most of the geospatial data portals use keyword-based match to search data.
Yun Li, Yongyao Jiang, Justin C. Goldstein, Lewis J. Mcgibbney, Chaowei Yang   +4 more
doaj   +1 more source

Incrementality and intention-recognition in utterance processing

Dialogue & Discourse, 2011
Ever since dialogue modelling first developed relative to broadly Gricean assumptions about utter-ance interpretation (Clark, 1996), it has remained an open question whether the full complexity of higher-order intention computation is made use of in everyday conversation. In this paper we examine the phenomenon of split utterances, from the perspective
Gregoromichelaki, Eleni, Kempson, Ruth, Mills, Gregory James, Purver, Matt, Cann, Ronnie, Meyer Viol, Wilfried, Healey, Patrick G T   +6 more
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Multi-Layer Prompt Engineering for Intent Recognition in Travel Planning Assistants

Applied Sciences
Current travel planning tools suffer from information fragmentation, requiring users to switch between multiple apps for maps, weather, hotels, and other services, which creates a disjointed user experience.
Yijin Huang, Lanlan Ma, Yapeng Wang
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Business Intent and Network Slicing Correlation Dataset from Data-Driven Perspective

Scientific Data
Intent-Based Networking (IBN) is an emerging network management technology that enables automated configurations based on user intents. A critical aspect of IBN is the accurate and autonomous extraction of user intents and their translation into a ...
Jie Li, Sai Zou, Yanglong Sun, Hongfeng Gao, Wei Ni   +4 more
doaj   +1 more source