Results 101 to 110 of about 548,323 (297)

Autour de quelques valeurs de be to en anglais contemporain [PDF]

open access: yesStudii de Lingvistica
In most grammars, be to is treated as a modal periphrasis or construction, whose various interpretations derive from a primary semantic value, differing from one grammarian to another, which suggests the limits of such an approach.
Eric Gilbert
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

The Effect of Social Norms on Physicians’ Intentions to Use Liver Cancer Screening: A Cross-Sectional Study Using Extended Theory of Planned Behavior

open access: yesRisk Management and Healthcare Policy, 2022
Qingwen Deng,1,2 Wenbin Liu1 1Department of Health Management, School of Public Health, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2School of Public Health, Fudan University, Shanghai, 200032, People’s Republic of ...
Deng Q, Liu W
doaj  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Relief of intention tremor by thalamic surgery. [PDF]

open access: bronze, 1970
K Samra   +4 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Healthy Sleepers Can Worsen Their Sleep by Wanting to Do so: The Effects of Intention on Objective and Subjective Sleep Parameters

open access: yesNature and Science of Sleep, 2020
Selina Ladina Combertaldi, Björn Rasch Division of Cognitive Biopsychology and Methods, Department of Psychology, University of Fribourg, Fribourg, FR, SwitzerlandCorrespondence: Björn RaschDivision of Cognitive Biopsychology and Methods ...
Combertaldi SL, Rasch B
doaj  

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