Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Predictors of lung cancer patients' behavioral intention to use virtual reality for treatment preparedness and shared decision-making: a Unified Theory of Acceptance and Use of Technology-based perception study. [PDF]
Elkefi S +5 more
europepmc +1 more source
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Is it drinking poison to quench thirst? Learners' risk awareness and continuance intention to use GAI in L2 writing. [PDF]
Kong B, Maruthai E.
europepmc +1 more source
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
From facilitating conditions to intention to use internet hospitals among doctors: multiple mediators of perceived risk and performance expectancy. [PDF]
Luo T +7 more
europepmc +1 more source
A study on satisfaction of using smartphone, continuance intention and recommendation intention
null 정지희, null ChungKiHan
openaire +1 more source
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Applying the UTAUT Model to Analyze Healthcare Professionals' Behavioural Intention to Use Hospital Information Systems: A Cross-Sectional Study in a Multi-Specialty Hospital. [PDF]
Sriram S, Priya SN, Bhoomadevi A.
europepmc +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source

