Results 61 to 70 of about 367,581 (336)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Self-Deception: Intentional Plan or Mental Event?

open access: yesHumana.Mente: Journal of Philosophical Studies, 2012
The focus of this paper is the discussion between supporters of the intentional account of SD and supporters of the causal account. Between these two options the author argues that SD is the unintentional outcome of intentional steps taken by the agent ...
Anna Elisabetta Galeotti
doaj  

Proč Láokoón nekřičí? K diskontinuitám v poznání // Why does not Laocoon scream? On discontinuities in knowledge [PDF]

open access: yesSvět Literatury, 2017
The paper deals with the central problem of Lessing’s Laocoön „Why does not marble Laocoön in his famous depiction scream?“ against division of our experience into scientific knowledge and art.
Vojtěch Kolman
doaj  

The study of theology and religion at the University of Pretoria: Two epochs of endeavor

open access: yesHTS Teologiese Studies/Theological Studies, 2017
This article explores the possibility of an alignment of (a) theology (understood as study concentrating on one faith from the faith suppositions of that faith) and (b) a study of world religions, open to all regardless of faith in the context of an ...
J.S. (Kobus) Krüger
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Evaluating the Bayesian causal inference model of intentional binding through computational modeling

open access: yesScientific Reports
Intentional binding refers to the subjective compression of the time interval between an action and its consequence. While intentional binding has been widely used as a proxy for the sense of agency, its underlying mechanism has been largely veiled ...
Takumi Tanaka
doaj   +1 more source

The Causal Relevance and Heterogeneity of Program Explanations in the Face of Explanatory Exclusion [PDF]

open access: yesKritike: An Online Journal of Philosophy, 2008
In everyday causal explanations of human behaviour, known generally as folk psychology,' the causal powers of the mental seem to be taken for granted. Mental properties such as perceptions, beliefs, and desires, are all called upon in causal explanations
Wilson Cooper
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Para ler Jon Elster: limites e possibilidades da explicação por mecanismos nas ciências sociais

open access: yesDados: Revista de Ciências Sociais, 2003
The article aims to investigate and discuss not only the innovations but also the limitations, tensions, and gaps in Jon Elster's methodological concepts, characterized by a type of intentional-causal explanation whose premise is methodological ...
Ratton Júnior José Luiz de Amorim   +1 more
doaj  

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