Results 191 to 200 of about 176,859 (312)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Attention to greatness: Buddhaghosa [PDF]

, 2018
Ganeri, Jonardon
core  

The Role of Intentional Stance Beliefs and Agent Appearance on Gaze Use during Joint Attention

Friederike Charlotte Hechler, Emily S. Cross, G Ann Perez, Aitor Miguel Blanco, Patrick Nalepka, Nathan Caruana   +5 more
openalex   +2 more sources

The Relevance of Empathy to the Intentionally Inviting Stance

, 2021
Tony Monahan
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Trigens can't swim: intelligence and intentionality in first person game worlds [PDF]

, 2008
Pinchbeck, Dan
core  

Expanding the Conversation on Qualitative Rigor in Medical Education Research. [PDF]

PRiMER
Rattanapitoon SK, La N, Arunsan P, Rattanapitoon NK.   +3 more
europepmc   +1 more source

Adopting the intentional stance interferes with social attention when interacting with a social robot

Serena Marchesi, Kyveli Kompatsiari, Davide De Tommaso, Agnieszka Wykowska   +3 more
openalex   +2 more sources

Repressed Contents Reconsidered:Repressed Contents and Dennett’s Intentional Stance Approach

, 2007
Vesa Talvitie
openalex   +2 more sources