Results 71 to 80 of about 3,705 (232)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Towards an Architecture for Semiautonomous Robot Telecontrol Systems.
, 2009 The design and development of a computational system to support robot–operator collaboration is a challenging task, not only because of the overall system complexity, but furthermore because of the involvement of different technical and scientific ...
Triviño Barros, Gracián +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2006 Mainstream philosophy of action and mind construes intentional behaviour in terms of causal processes that lead from agent-involving mental states to action. Actions are construed as events, which are actions in virtue of being caused by the right mental
Markus Ernst Schlosser +1 more
core
Metaphor and the Intentional Stance: On John Searle's Criticism of Comparison Theory of Metaphor [PDF]
, 2015 塞尔在对隐喻的比较主义批判的基础上,提出了隐喻性解释的三个步骤和八项原则,以建立一个完备的隐喻理论。但是塞尔重复了布莱克的一些错误,对比较主义的核心论题存在两个方面的误解,他所建立的隐喻解释原则过于宽泛,最后无法避免将隐喻打回术语学解释范围。为了避免把对隐喻的解释仅仅归纳入术语学的范围,文末在分析塞尔关于隐喻的两大反驳论证的基础上,来理清其隐喻理论的核心和缺陷,引入镜像神经元概念来为隐喻的研究提供反驳的基础,并引证来自心理学研究和神经科学研究的其他证据提供支持。John Searle proposed ...
冯艳霞
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Specification and Implementation of a Belief-Desire-Joint-Intention Architecture for Collaborative Problem Solving [PDF]
, 1993 Systems composed of multiple interacting problem solvers are becoming increasingly pervasive and have been championed in some quarters as the basis of the next generation of intelligent information systems.
Jennings, N. R. +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A compatibilist characterization of free will using the intentional stance
, 1983 The purpose of this paper is to give a compatibilist characterization of free will, First, the concept of intentionality is introduced. Following Daniel Dennett, it is proposed that the attribution of physical, functional, or intentional entities to a ...
Sanders, Robert Bruce
core