Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Deciding to Be Left Alone After Being Left Out: Behavioral Responses to Social Exclusion in Schizophrenia. [PDF]
Weittenhiller LP, Kring AM.
europepmc +1 more source
The Relationship Between Service Quality, Satisfaction and Behavioral Intentions of Tourists: The Case of Hau Giang Province, Vietnam [PDF]
Trong Nhan Nguyen +3 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Effects of housing purchase restriction policies on the urban settlement intentions of migrant populations. [PDF]
Sun J, Wang S, Feng S, Li X.
europepmc +1 more source
Environmental Sustainability and Green Revisit Intentions: The Mediating Effect of Green Satisfaction in Selected Hotels in the Ashanti Region of Ghana [PDF]
Barbara Botwe +3 more
openalex +1 more source
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Between Class and Career: Applying the Job Demands-Resources Model to Working College Students. [PDF]
Tooley KM +6 more
europepmc +1 more source

