The good intentions of the minister of justice do not justify the means
Olaś, Andrzej
openalex +1 more source
TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Correction: Attitudes and intentions toward prostate cancer screening among males in China: a qualitative study. [PDF]
Hao S +5 more
europepmc +1 more source
Decoding Users’ Continuance Intentions towards Digital Financial Platforms in the Indian Economy
Anandhi Elangovan, M. Babu
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Emotions, perceived risk and intentions to adopt emerging e-banking technology amongst educated young consumers [PDF]
Masoome Abikari
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Beyond emotions: Social cognitive predictors of COVID-19 vaccination intentions before and after vaccine roll-out. [PDF]
Manoli A +37 more
europepmc +1 more source
Fertility Intentions and Outcomes: The Role of Policies to Close the Gap
Dimiter Philipov
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source

