Results 11 to 20 of about 30,318 (247)

Business, Indigenous Peoples’ Rights and Security in the Case Law of the Inter-American Court of Human Rights [PDF]

, 2019
The history of indigenous peoples from across the globe is marked by constant aggression, persecution and conflict. In these times, they are being obliged to confront the consequences of economic interests in their ancestral lands and natural resources ...
Reguart-Segarra, Núria
core   +1 more source

The Inter-American System for the Protection of Human Rights and Persons with Disabilities: challenges and perspectives beyond the non-discrimination rule [PDF]

, 2021
The present article focuses on the InterAmerican System for the Protection of Human Rights (Inter-American System) in the context of disability. It addresses several relevant issues regarding complaint mechanisms.
Andrés Mauricio Guzmán Rincón, Caballero Pérez, Adriana, Guzmán Rincón, Andrés Mauricio, Adriana Caballero Pérez, Caballero Perez, Adriana; id_orcid   +4 more
core   +1 more source

Bridging the Gap: National Human Rights Institutions and the Inter-American Human Rights System [PDF]

, 2018
Increasing attention is being paid to how the Inter-American Human Rights System (IAHRS) informs human rights practice. In this task, national human rights institutions (NHRIs) have emerged as potentially important intermediaries, serving as a possible ...
Pegram, T, Tom Pegram, Rodriguez, NH, Nataly Herrera Rodriguez   +3 more
core   +1 more source

THE ORIGIN OF THE MARGIN OF APPRECIATION AND THE JURISPRUDENCE OF THE EUROPEAN SYSTEM OF HUMAN RIGHTS AND INTER-AMERICAN SYSTEM OF HUMAN RIGHTS

, 2021
This study seeks to study the margin of appreciation doctrine and its implementation by the European System of Human Rights and Inter-American System of Human Rights. This doctrine originated in the European System and was developed by the European Court
Guerra, Raquel
core   +1 more source

Part Two The Doctrine and Practice of the Inter-American System, 10 Women’s Rights, Gender, and Sexuality

, 2019
This chapter examines the inter-American system’s response to gender-based human rights violations, particularly the Commission and Court’s jurisprudence on violence and discrimination against women, and women’s access to social, economic, procedural ...
Duhaime, Bernard, Naddeo, Cecilia, Guzmán, Diana, Sandoval, Clara, Brewer, Stephanie Erin, Vargas, Claret, Bettinger-Lopez, Caroline, Cavallaro, James L.   +7 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Strengthening the impact of the Inter-American Human Rights System through scholarly research: reflective report [PDF]

, 2016
This Report contains the collective findings of the Inter-American Human Rights Network, a multi-disciplinary group of international scholars of the Inter-American Human Rights System (IAHRS) brought together to gain richer insights into three sets of ...
Hillebrecht, C, Sandoval, C, Engstrom, P, Huneeus, A, Low, P   +4 more
core  

Toward Universal Birth Registration: A Systemic Approach to the Application of ICT

, 2015
This publication is the result of the technical and financial collaboration of the Instituto para el Desarrollo Social Argentina under leadership of the Inter-American Development Bank and the United Nations Children\u27s Fund.
Inter-American Development Bank
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source