VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Dynamic Consistency-Aware Multi-View Learning with SAM3 for 3D Medical Image Segmentation. [PDF]
Sensors (Basel)Chen X, Chen S.
europepmc +1 more source
Advanced Science, EarlyView.Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
Simultaneous Quantification of Vedolizumab, Ustekinumab, and Infliximab in Human Serum by LC-MS/MS: Application to Therapeutic Drug Monitoring in Inflammatory Bowel Disease. [PDF]
Drug Des Devel TherZhang Y +7 more
europepmc +1 more source
Using UPLC-MS/MS and LC-MS/MS to Investigate the Pharmacokinetics in SD Rat Plasma and Tissue Distribution in KM Mice of Daphnoretin Nanomicelles. [PDF]
Biomed ChromatogrLv ZM +13 more
europepmc +1 more source
Using a monoplane stereoscopic videoradiography configuration to accurately measure skeletal positions: a proof-of-concept study. [PDF]
Med Eng PhysBugajski T, Lichti DD, Zandiyeh P.
europepmc +1 more source
Personalized Calibration and Hybrid Feature Fusion for Continuous Blood Pressure Estimation Using PPG and ECG Signals. [PDF]
Sensors (Basel)Zhang Z, Qu P, Tang H.
europepmc +1 more source