Results 61 to 70 of about 838,326 (247)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

MoE Based Consistency and Complementarity Mining for Multi-View Clustering

Algorithms
Multi-view clustering, which improves clustering performance by using the complementary and consistent information from multiple diverse feature sets, has been attracting increasing research attention owing to its broad applicability in real world ...
Xiaoping Wang, Yang Cao, Yifan Zhang, Hanlu Ren, Qiyue Yin   +4 more
doaj   +1 more source

Academic job satisfaction questionnaire: Construction and validation in Saudi Arabia

Journal of Family and Community Medicine, 2011
Background: Colleges and universities are becoming increasingly accountable for teaching outcomes in order to meet rigorous accreditation standards. Job satisfaction (JS) seems more difficult to measure in the academic field in view of the complexity of ...
Abdullah M Al-Rubaish, Sheikh Idris A Rahim, Mahdi S Abumadini, Lade Wosornu   +3 more
doaj   +1 more source

FADI: a fault-tolerant environment for open distributed computing [PDF]

, 2000
FADI is a complete programming environment that serves the reliable execution of distributed application programs. FADI encompasses all aspects of modern fault-tolerant distributed computing. The built-in user-transparent error detection mechanism covers
A. Bargiela, BARGIELA, ELNOZAHY, JANAKIRAMAN, LAMOTTE, OSMAN, OSMAN, PLANK, POWELL, RIBERIO, SENS, SILVA, T. Osman   +12 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tensorized Multi-View Subspace Clustering via Tensor Nuclear Norm and Block Diagonal Representation

Mathematics
Recently, a growing number of researchers have focused on multi-view subspace clustering (MSC) due to its potential for integrating heterogeneous data. However, current MSC methods remain challenged by limited robustness and insufficient exploitation of ...
Gan-Yi Tang, Gui-Fu Lu, Yong Wang, Li-Li Fan   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Development and Validation of an Instrument for the Measurement of Health-Related Quality of Life Based on View of Traditional Chinese Medicine Perspective

Journal of Traditional and Complementary Medicine, 2012
Objectives: The objectives of this study were to develop and validate an instrument for the measurement of health-related quality of life (HRQoL) based on view of Traditional Chinese Medicine (TCM).
Hen-Hong Chang, Wei-Chu Chie, Yung-Hsin Chin, Ching-Ping Hsu, Tsang-Wu Liu, Jacqueline Whang-Peng   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source