Results 51 to 60 of about 55,703 (289)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Photoionization models of the Eskimo nebula: evidence for a binary central star? [PDF]

, 2011
The ionizing star of the planetary nebula NGC 2392 is too cool to explain the high excitation of the nebular shell, and an additional ionizing source is necessary. We use photoionization modeling to estimate the temperature and luminosity of the putative
Danehkar, Ashkbiz, De Marco, Orsola, Frew, David J., Parker, Quentin A.   +3 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rapid Binary Mass Transfer: Circumbinary Outflows and Angular Momentum Losses

The Astrophysical Journal
High rates of stable mass transfer likely occur for some binary star systems, but the resulting flow of mass and angular momentum (AM) is unclear. We perform hydrodynamical simulations of a polytropic donor star and a point-mass secondary to determine ...
Peter Scherbak, Wenbin Lu, Jim Fuller
doaj   +1 more source

Hyperons in Neutron Stars

Universe, 2021
I review the issues related to the appearance of hyperons in neutron star matter, focusing in particular on the problem of the maximum mass supported by hyperonic equations of state. I discuss the general mechanism that leads to the formation of hyperons
Domenico Logoteta
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring Mass Transfer Mechanisms in Symbiotic Systems

The Astrophysical Journal
We define two regimes of the parameter space of symbiotic systems based on the dominant mass transfer mechanism. A wide range of white dwarf (WD) mass, donor mass, and donor radius combinations are explored to determine the separation for each parameter ...
Irin Babu Vathachira, Yael Hillman, Amit Kashi   +2 more
doaj   +1 more source

Interacting X-ray Binaries in Globular Clusters: 47Tuc vs. NGC 6397

, 2005
Our deep Chandra exposures of 47Tuc and moderate exposures of NGC 6397 reveal a wealth of new phenomena for interacting X-ray binaries (IXBs) in globular clusters.
Grindlay, Jonathan E.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source