Results 21 to 30 of about 114,522 (217)

DIGITAL DECISION-MAKING TECHNOLOGIES: CROWDSOURCING AS A FORM OF POLITICAL PARTICIPATION

open access: yesВестник университета, 2020
In the era of the fourth industrial revolution, a “smart” society is being formed, whose members are able to acquire and apply new competencies, including in the field of political management.
O. V. Erokhina
doaj   +1 more source

Theoretical foundations and practical tasks of optimizing the political system of modern Ukrainian society

open access: yesПолітичні дослідження, 2023
Thearticledealswiththeneedtofurtherimprovement ofthefunctioningofthepoliticalsystemofmodernUkrainiansociety. The relevance of this task is determined by the severity of manifestations of opposition from higher authorities.
Mykola Ivanov
doaj   +1 more source

Public government and civil society institutions: shaping legal groundwork for regional collaboration

open access: yesЮридический вестник Самарского университета
The article explores the legal forms of interaction between civil society institutions and regional public authorities, focusing on how these interactions contribute to building trust between civil society and government in the subjects of the Russian ...
E. E. Nikitina
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Сommunicative strategy of Kyiv: required need and main principles of formation

open access: yesІнтегровані комунікації, 2017
Communication between local governments and the public is an important component of democratic development of the state, formation and development of civil society and socially and politically active citizens. The Revolution of Dignity in 2014 activated
Tetiana Guzenko
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The role of Russian mass media in the system of communicative relations between the state and society. Review of Markov, E.A. Rossiiskaya vlast' i SMI: istoriya informatsionnogo vzaimodeistviya: monografiya [Russian authorities and mass media: the history of information interaction: a monograph]. Moscow: RUSAINS, 2021.

open access: yesHistoria provinciae: журнал региональной истории, 2022
The proposed work analyzes a monograph published in 2021 by Evgenii A. Markov, Doctor of Political Sciences, Professor of the Department of Social Communications and Media of Cherepovets State University.
Arbakhan K. Magomedov
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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