Results 121 to 130 of about 34,703 (309)

Remarks on deixis [PDF]

, 1992
The prevailing conception of deixis is oriented to the idea of 'concrete' physical and perceptual characteristics of the situation of speech. Signs standardly adduced as typical deictics are I, you, here, now, this, that. I and you are defined as meaning
Fuchs, Anna
core  

Magazine and reader constructions of 'metrosexuality' and masculinity: a membership categorisation analysis [PDF]

, 2011
Since the launch of men's lifestyle magazines in the 1980s, academic literature has predominantly focused on them as a cultural phenomenon arising from entrepreneurial and commercial initiatives and/or as cultural texts that proffer representations of ...
Baker C.D., Ballaster R., Beck U., Benwell B., Berger J., Beynon J., Brendan Gough, Chapman R., Coad D., Connell R.W., Edwards T., Edwards T., Edwards T., Featherstone M., Gill R., Hall M., Hermes J., Hester S., Jackson P., Jayyusi L., Jefferson G., Matthew Hall, McRobbie A., McRobbie A., Moore S., Morley D., Osgerby B., Sacks H., Simpson M., Stevenson N., Taylor Y., Vallis R., Wheaton B., Whitehead S.M.   +33 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The use of interactional metadiscourse features to present a textual voice: A case study of undergraduate writing in two departments at the University of Botswana

Reading & Writing, 2017
In recent years, there has been an increased emphasis on the interpersonal function of metadiscourse features in academic texts. This means that research on writing in academic contexts began to focus on the rhetorical features, such as interactional ...
Boitumelo T. Ramoroka
doaj   +1 more source

What\u27s going on here? Deconstructing the interactive encounter. [PDF]

, 2010
Eleanor Clarke Sagle ...
Burke, Janice P
core   +1 more source

Stance-taking and public discussion in blogs. [PDF]

, 2010
Blogs, which can be written and read by anyone with a computer and an internet connection, would seem to expand the possibilities for engagement in public sphere debates.
Myers, Greg
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Profiling the Use of Attitude Markers, Boosters and Hedges in Academic Written Production of International Student Mobility Participants

Journal of Language and Education
Background: Motivated by the growing interest in the impact of study abroad programs on language development, the present research addresses a gap in the literature by examining the often-overlooked role of metadiscourse markers in writing.
Саня Маринов, Mirna Varga
doaj   +1 more source