Results 201 to 210 of about 3,269,262 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Interplay of the ribosome A and CAR sites. [PDF]

NAR Genom Bioinform
Raval M, Zhou Y, Lynch M, Krizanc D, Thayer KM, Weir MP.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis. [PDF]

Nat Commun
Auguin D, Lannes L, Kikuti C, Ayoub N, Juillé M, Réty S, Nandwani N, Pathak D, Ruppel KM, Spudich JA, Robert-Paganin J, Houdusse A.   +11 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Correction: A tripartite bacterial-fungal-plant symbiosis in the mycorrhiza-shaped microbiome drives plant growth and mycorrhization

Microbiome
Changfeng Zhang, Marcel G. A. van der Heijden, Bethany K. Dodds, Thi Bich Nguyen, Jelle Spooren, Alain Valzano‑Held, Marco Cosme, Roeland L. Berendsen   +7 more
doaj   +1 more source

Inferring signed social networks from contact patterns. [PDF]

J Phys Complex
Ferenczi D, Young JG, Peel L.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Large scale phage-antibiotic combination studies reveal key combinations for urinary tract infection and urosepsis treatments

Clokie M, Michniewski S, Wildsmith C, Jameson E, Brown N, Daum A, Akter M, Attwood M, Mahony J, Gazioglu O, Sutton J, Adler K, Textor M, Sicheritz-Pontén T, Millard A, Haines M.   +15 more
europepmc   +1 more source

High-throughput small-angle X-ray scattering reveals effective structure factor transitions linked to high-concentration antibody viscosity. [PDF]

MAbs
Kalejaye L, Wu IE, Chu JM, Shah M, Castellanos MM, Chodankar S, Mody N, Lai PK.   +7 more
europepmc   +1 more source