Results 231 to 240 of about 9,657,547 (300)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Decoding Polyether-Cation Interactions: Computational Strategies for Agricultural Applications. [PDF]

Polymers (Basel)
Damante JVJ, da Silva EE, Alves FB, Fico BA, Parreira RLT, Molina EF, Orenha RP.   +6 more
europepmc   +1 more source

Wildlife Tourism Opens Opportunities to Explore Agonistic Interactions Among Elusive Neotropical Cats. [PDF]

Ecol Evol
Tortato FR, Sepulvida R, Barragan J, Boron V, Rincón S, Hoogesteijn R.   +5 more
europepmc   +1 more source

System drift in the evolution of plant meristem development. [PDF]

PLoS Genet
van der Jagt PL, Oud S, Vroomans RMA.
europepmc   +1 more source

Comparative performance of large language models and Drugs.com versus Lexicomp for antiseizure medication drug-drug interactions: A cross-sectional study with iterative prompting analysis. [PDF]

Explor Res Clin Soc Pharm
Mohammed M, Khan MA, Chaudhary V, Alsaleh H, Fatima SB, Pal B.   +5 more
europepmc   +1 more source