Results 91 to 100 of about 1,506,657 (303)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu   +13 more
wiley   +1 more source

A Report from the International Scientific Conference “Theoretical and Practical Aspects of Distance learning” DLCC2025 (www.dlcc.us.edu.pl) subtitled: “E-learning & Interactive Learning. Generative Artificial Intelligence (GAI), Gamification and Immersive Technologies (AR/VR) in Educational Practice and Research” which was held at the University of Silesia, Cieszyn, Poland on October 15 and 16, 2025

open access: yesInternational Journal of Research in E-Learning
The 17th edition of the International Scientific Conference, “Theoretical and Practical Aspects of Distance learning” DLCC2025 (www.dlcc.us.edu.pl) was held under the theme “E-learning & Interactive Learning.
Eugenia Smyrnova-Trybulska
doaj   +1 more source

Interactive practices and identity construction in W. Wordsworth’s “Preface” to Lyrical Ballads (1800): a historical pragmatic scrutiny [PDF]

open access: yesStudii de Lingvistica, 2017
This article analyses the linguistic practices utilised by W. Wordsworth in the “Preface” to the second edition of Lyrical Ballads (1800) in order to construct his own identity as an innovative writer and his interaction with his reader. Within the aims
Daniela Francesca Virdis
doaj  

ACCUPLACER math full study guide: complete math review, online video lessons, 4 full practice tests book + online, 280 realistic questions, plus online flashcards

open access: yes, 2020
The Smart Edition ACCUPLACER Math study guide contains complete math review including video lessons, 4 Full practice tests both in the book + online with 280 realistic questions PLUS online ...
Edition, Smart
core  

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

open access: yesAdvanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh   +4 more
wiley   +1 more source

Gdy pisarz staje się dziennikarzem. Kilka uwag o „Gazecie Pisarzy”

open access: yesAnnales Universitatis Paedagogicae Cracoviensis. Studia Linguistica, 2018
The article stems from a media linguistic perspective and serves as a case study for comparing the roles of a journalist and a writer. The author chose a textual experiment for that purpose, namely the 23–24 April 2016 edition of Gazeta Wyborcza, a ...
Magdalena Ślawska
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li   +21 more
wiley   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han   +24 more
wiley   +1 more source

Nationalism Edition Interactive Textbook: Solution to Enhance National Insight of Migrant Worker’s Children in Malaysia

open access: yesJurnal Kewarganegaraan
The effort to preserve national identity has become an increasingly difficult challenge for Indonesian Migrant Worker children in Malaysia, who are often separated from Indonesian culture and educational systems. Growing up in a multicultural environment,
Jennie Nabilah   +2 more
doaj   +1 more source

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

open access: yesAdvanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke   +32 more
wiley   +1 more source

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