Results 211 to 220 of about 1,506,657 (303)

A rock brittleness index based on the postpeak energy release rate and damage surface characteristics for brittle hard rock

open access: yesDeep Underground Science and Engineering, EarlyView.
This study examines energy evolution in rock rupture via triaxial direct shear tests, exploring the impact of confining pressure and temperature on fracture surface randomness. A novel energy‐based brittleness index is proposed, validated experimentally, and compared with existing methods for reliability and accuracy.
Biao Wang   +5 more
wiley   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard   +3 more
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová   +5 more
wiley   +1 more source

eHealth in the management of PTSD in children and adolescents: a scoping review. [PDF]

open access: yesFront Psychol
Ju L   +7 more
europepmc   +1 more source

Ecological Momentary Interventions in the Management of Eating Disorders and Obesity: A Systematic Review

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This systematic review evaluated the feasibility, efficacy, adherence, and methodological quality of ecological momentary intervention (EMI)–based treatments for individuals with diagnosed eating disorders (EDs) and/or obesity. Method Eight electronic databases were systematically searched from inception to January 2026.
Wenlu Mao   +4 more
wiley   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning   +2 more
wiley   +1 more source

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