Results 121 to 130 of about 2,327,239 (397)

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye   +13 more
wiley   +1 more source

Reservoir hill and audiences for online interactive drama [PDF]

open access: yes, 2011
This paper analyses the interactive experiences constructed for users of the New Zealand online interactive drama Reservoir Hill (2009, 2010), focusing both on the nature and levels of engagement which the series provided to users and the difficulties of
Hardy, Ann   +2 more
core  

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

open access: yesAdvanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li   +20 more
wiley   +1 more source

ABC online : a vortal for new opportunities?

open access: yes, 2007
This article undertakes an analysis of the ABCs website, ABC Online -- www. abc.net.au -- to explore how the public broadcaster uses the Internet to offer new services.
Cinque, Toija
core  

BMSC‐NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration

open access: yesAdvanced Science, EarlyView.
A novel strategy for integrated osteochondral tissue regeneration using BMSC‐NFMCs, this study has demonstrated the precise regulation of vascularization and effective interface integration using optimized nanofibrous materials and innovative construction methods.
Qian Zhou   +8 more
wiley   +1 more source

Analysis and Implement of Broadcast Program Monitoring Data

open access: yesMATEC Web of Conferences, 2016
With the rapid development of the radio and TV industry and the implementation of INT (the integration of telecommunications networks, cable TV networks and the Internet), the contents of programs and advertisements is showing massive, live and ...
Song Jin Bao, Huang Lun Lun
doaj   +1 more source

Science and Technology in Media [PDF]

open access: yes, 2015
Tato práce se zabývá vlivem médií, především nových médií, na oblast vědy a techniky. Definuje základní mediální pojmy a upozorňuje na to, že média mohou být výborným prostředkem k propagaci vědy a techniky, ale mají také obrovskou moc a mohou zkreslovat
Gellnerová, Zuzana
core  

BRD4 Signaling Maintains the Differentiated State of β Cells

open access: yesAdvanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu   +22 more
wiley   +1 more source

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

open access: yesAdvanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu   +7 more
wiley   +1 more source

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