Results 221 to 230 of about 77,671 (281)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Adopting a user-centred design approach for the development of on-device technology to prevent the viewing of child sexual abuse material: app design insights and principles from the development of 'Salus'. [PDF]

Front Psychiatry
Davy D, Beaufoy S, Bogaerts S, De Boeck M, De Caluwé E, Efthymiadou E, Joy R, Kamitz L, Kleijn M, Nentzl J, Smith L, Van Puyvelde L, Wefers S, Lundrigan S.   +13 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Virtualizing Alcohol Use Disorder Therapy: A Systematic Scoping Review. [PDF]

Adv Ther
Bazhanov A, Meixner G.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Effects of Driving Task Demands and Information Load on AR-HUD Cognitive Efficiency: The Moderating Role of Working Memory Capacity in a VR-Based Simulated Driving Environment. [PDF]

J Eye Mov Res
Li J, Lin M, Feng X, Zhang H, Wang C, Ma Y.   +5 more
europepmc   +1 more source

Addressing challenges for virtual reality applications in the ICU. [PDF]

J Anesth Analg Crit Care
Cascella M.
europepmc   +1 more source

How Users Perceive and Respond to Digital Humans: A Scoping Review of Agency, Embodiment, Social Role, and Response Outcomes. [PDF]

Behav Sci (Basel)
Gong X, Zeng L.
europepmc   +1 more source

A full review of online education resources available on antifungal stewardship. [PDF]

JAC Antimicrob Resist
Abraham K, Dellière S, Smith DJ, Stone N, Rautemaa-Richardson R.   +4 more
europepmc   +1 more source

The modulating role of sources of difficulty in interactive matchstick algebra. [PDF]

Front Psychol
Spiridonov V, Erofeeva M, Klowait N, Morozov M, Ardislamov V.   +4 more
europepmc   +1 more source