Results 51 to 60 of about 9,833,490 (279)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ModellingThe identification of interdependent edges plays a critical role in improving information propagation efficiency and enhancing network robustness in interdependent networks.
Qingyu Zou, Yue Gong
doaj +1 more source
Generalized Mutual Synchronization between Two Controlled Interdependent Networks
Abstract and Applied Analysis, 2014 This paper mainly focuses on the generalized mutual synchronization between two controlled interdependent networks. First, we propose the general model of controlled interdependent networks A and B with time-varying internetwork delays coupling. Then, by
Quan Xu +4 more
doaj +1 more source
IEEE Access, 2020 As the backbone of many real-world complex systems, networks interact with others in nontrivial ways from time to time. It is a challenging problem to detect subgraphs that have dependencies on each other across multiple networks.
Fei Jie +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Optimal Facility Location for Interdependent Infrastructure Network Recovery [PDF]
, 2017 Modern communities heavily depend on critical infrastructure networks such as power, water, transportation, telecommunications, gas, etc. Since daily life requires these networks to be operational, it is important that they are able to withstand or ...
Mooney, Elyssa
core
The Sense of Cooperation on Interdependent Networks Inspired by Influence-Based Self-Organization
Mathematics, 2023 Influence, as an inherently special attribute, is bound to profoundly affect a player’s behavior. Meanwhile, a growing body of studies suggests that interactions among networks may be more important than isolated ones.
Xiaopeng Li +3 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Robust Resource Allocation to Interdependent Networks under Multiple Disruption Scenarios [PDF]
, 2017 In recent years, the threat of international attacks on critical infrastructure networks has grown; as defined by a 1998 Presidential Decision Directive, these are networks necessary to society’s functionality and include water, power, communication ...
Lobban, Hannah
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