Results 51 to 60 of about 4,752,162 (286)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
International Journal of Public HealthObjectiveThis research conducted two studies in South Korea to explore the relationship between smokers’ self-construals and the types of cigarettes they use, emphasizing their combined effects on cessation campaign effectiveness.MethodsStudy 1 explored ...
Dong Hoo Kim, Ji Mi Hong
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Price of Anarchy of Simple Auctions with Interdependent Values
CoRR, 2020 We expand the literature on the price of anarchy (PoA) of simultaneous item auctions by considering settings with correlated values; we do this via the fundamental economic model of interdependent values (IDV). It is well-known that in multi-item settings with private values, correlated values can lead to bad PoA, which can be polynomially large in the
Alon Eden +3 more
openaire +3 more sources
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
DRIVING OF STRUGGLE VALUES AS MORAL PRESSURE TO CONSTRUCT THE KHAYRA UMMAH SYSTEM
The International Journal of Humanities Technology and Civilization, 2023 The drive of struggle values and moral pressure in social systems and organizations are interdependent. A good social system is strongly influenced by the values of struggle and moral pressure, so that everything contained in struggle and morality is ...
Abdur Rofik +7 more
doaj +1 more source
Optimal and Robust Mechanism Design with Interdependent Values [PDF]
ACM Transactions on Economics and Computation, 2016 We study interdependent value settings and extend several results from the well-studied independent private values model to these settings. For revenue-optimal mechanism design, we give conditions under which Myerson's virtual value-based mechanism remains optimal with interdependent values. One of these conditions is robustness of the truthfulness and
Tim Roughgarden, Inbal Talgam-Cohen
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New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Hybrid Decision-Making Evaluation for Future Scenarios of Cultural Ecosystem Services
Land, 2020 In the face of rapid urbanization and globalization, the continual loss of rural landscapes is occurring globally because of declining rural industries, abandoned farmlands and aging local populations. These problems highlight the versatility and diverse
Li-Pei Peng, Wei-Ming Wang
doaj +1 more source