Results 51 to 60 of about 5,084,019 (288)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Voting with interdependent values: The condorcet winner

, 2023
We generalize the standard, private values voting model with single-peaked preferences and incomplete information by introducing interdependent preferences.
Kleiner, Andreas, Moldovanu, Benny, Gershkov, Alex, Shi, Xianwen   +3 more
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Unveiling the Impact of Smokers’ Self-Construals on the Effectiveness of Smoking Cessation Campaigns: A Comparative Analysis of E-Cigarettes and Combustible Cigarettes

International Journal of Public Health
ObjectiveThis research conducted two studies in South Korea to explore the relationship between smokers’ self-construals and the types of cigarettes they use, emphasizing their combined effects on cessation campaign effectiveness.MethodsStudy 1 explored ...
Dong Hoo Kim, Ji Mi Hong
doaj   +1 more source

Reputation Effects Under Interdependent Values [PDF]

SSRN Electronic Journal, 2016
I study reputation effects when the uninformed short run players' payoffs depend directly on the informed long run player's private information, i.e. values are interdependent. In this scenario, convincing the short run players that an action will be played does not guide them how to best respond.
openaire   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

DRIVING OF STRUGGLE VALUES AS MORAL PRESSURE TO CONSTRUCT THE KHAYRA UMMAH SYSTEM

The International Journal of Humanities Technology and Civilization, 2023
The drive of struggle values and moral pressure in social systems and organizations are interdependent. A good social system is strongly influenced by the values of struggle and moral pressure, so that everything contained in struggle and morality is ...
Abdur Rofik, Imron Rosyadi Hamid, Abdillah U. Djawahir, Muhammad Romli M., Prayogi R. Saputra, Fahrur Razi, Abu Amar Bustomi, Fajar Arianto   +7 more
doaj   +1 more source

Price of Anarchy of Simple Auctions with Interdependent Values

CoRR, 2020
We expand the literature on the price of anarchy (PoA) of simultaneous item auctions by considering settings with correlated values; we do this via the fundamental economic model of interdependent values (IDV). It is well-known that in multi-item settings with private values, correlated values can lead to bad PoA, which can be polynomially large in the
Alon Eden, Michal Feldman, Inbal Talgam-Cohen, Ori Zviran   +3 more
openaire   +3 more sources

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source