Results 31 to 40 of about 1,505,777 (298)

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Interdisciplinary Research: An Important Contribution to Dementia Care

Journal of Multidisciplinary Healthcare, 2022
Tanja Louise Ibsen,1 Siren Eriksen1,2 1Norwegian National Advisory Unit on Aging and Health (Aging and Health), Vestfold Hospital Trust, Tønsberg, Norway; 2Lovisenberg Diaconal University College, Oslo, NorwayCorrespondence: Tanja Louise Ibsen, Email ...
Ibsen TL, Eriksen S
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Making Mountains out of Molehills: Challenges for Implementation of Cross-Disciplinary Research in the Big Data Era [PDF]

, 2019
We present a “Researcher’s Hierarchy of Needs” (loosely based on Maslow’s Hierarchy of Needs) in the context of interdisciplinary research in a “big data” era.
Andresen, Daniel, Vasserman, Eugene
core   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Labour of Thought

Exchanges
In this reflective article we explore interdisciplinarity in practice. We begin from the position that interdisciplinary work provides great potential and acknowledge that it has become increasingly visible in discussions on the role that research can ...
Abiodun Egbetokun, Una MacGlone, Ed McKeon, Denis Newman-Griffis, Claire Sedgwick, Aikaterini Tavoulari   +5 more
doaj   +1 more source

Thematic Convergence of Iran's Scientific Productions in the Field of Health

مدیریت اطلاعات سلامت, 2019
Introduction: Considering the importance of health domain and proposed policies in the comprehensive scientific health plan, this study aimed to investigate the convergence of subjects in Iranian scientific productions in the field of health.
Fatemeh Parchami Pour, Hamzeali Nourmohammadi, Saeid Asadi   +2 more
doaj   +1 more source

Entrepreneurship - the Need for Interdisciplinary Research

Revista CEA, 2022
The area of research related to entrepreneurship is not homogeneous. Therefore, the interdisciplinary approach is the one that may successfully expand the domains of activities linked to making decisions about establishing and running an enterprise. This
Tomasz Bernat
doaj   +1 more source