Results 31 to 40 of about 205,852 (262)

“Big science” and interdisciplinary science

open access: yesAdvances in Physiology Education, 2005
The paper by Humphrey et al. (this volume) describes an innovative graduate program that seeks to foster interdisciplinary thinking and research in biomedical sciences and engineering. In reflecting on the manuscript, two observations about wider issues suggested themselves.
openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Putting the "E" in SES: unpacking the ecology in the Ostrom social-ecological system framework

open access: yesEcology and Society, 2015
The Ostrom social-ecological system (SES) framework offers an interdisciplinary tool for studies of linked human-natural systems. However, its origin in the social sciences belies the effectiveness of its interdisciplinary ambitions and undermines its ...
Jessica M. Vogt   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Developing computable sustainable urbanization science: interdisciplinary perspective

open access: yesComputational Urban Science, 2022
In this era of drastic global change, the Anthropocene, carbon neutrality and sustainable development have become common twenty-first century human challenges and goals. Large-scale urbanization is indicative of human activities and provides an important
Mingxing Chen   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

How to disarm an evolutionary trap

open access: yesConservation Science and Practice, 2019
Evolutionary traps occur when rapid environmental change leads animals to prefer resources (e.g., food, mates, habitats) that reduce their fitness. Traps can lead to rapid population declines, extirpation, and species extinction, yet they have received ...
Bruce A. Robertson, Daniel T. Blumstein
doaj   +1 more source

The ocean, our climate and the earth's health

open access: yesScientia Marina, 2001
The ocean is the major element controlling the long-term stability of the earth´s climate. It involves a complex pattern of interrelations between its physical, geological, chemical and biological components: the greater the complexity and diversity of ...
J. L. Pelegrí, I. Alonso, J. Arístegui
doaj   +1 more source

Transformation of Geography as an Interdisciplinary Science [PDF]

open access: yesInterdisciplinary Studies in the Humanities, 2016
Geography as a science of the spatial analysis of phenomena is based on three main objectives: studying spatial structures, examining the locational-spatial order of socio-economic activities, and searching spatial relationships and functions through ...
H. Afrakhteh
doaj   +1 more source

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