Results 161 to 170 of about 7,574,406 (265)

Impact of Simple Versus Complex Cannabis Advertising Messages and Warnings on US Young Adults' Product Perceptions. [PDF]

Subst Use Addctn J
Speer MB, LoParco CR, McCready DM, Cui Y, Chakraborty R, Thakkar S, Cavazos-Rehg PA, Berg CJ.   +7 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Gender, STEM career interest, and computational thinking: a social cognitive career theory perspective from Turkish adolescents. [PDF]

Sci Rep
Bars M.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Internet Searches for Vitamin A and Related Media Statements During the 2025 US Measles Outbreak.

JAMA Netw Open
Bischops AC, Nagorsen M, Madsen E, Majumder MS.   +3 more
europepmc   +1 more source

Interest in long-acting injectable ART among adolescents with perinatally acquired HIV in Cameroon: Implications for implementation in developing countries. [PDF]

PLOS Glob Public Health
Bouba Y, Ka'e AC, Ayafor C, Forgwei L, Gabisa JE, Mabongo D, Nka AD, Mejane RE, Tetang SN, Kamgaing RS, Ateba FN, Fainguem NN, Tchouaket MCT, Takou D, Kamgaing N, Menye MA, Noukayo F, Semengue ENJ, Basseck RW, Wiadamong A, Gnambi AR, Eyenga C, Etame NK, Ngueko AMK, Fotso LGM, Yimga JF, Beloumou GA, Chenwi CA, Sosso SM, Ketchaji A, Tchidjou HK, Ekane GEH, Koki PN, Armenia D, Colizzi V, Ajeh RA, Russo G, D'amelio S, Ceccherini-Silberstein F, Perno CF, Ndjolo A, Santoro MM, Fokam J.   +42 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Efficacy of Early Exposure Medical Programs for Underrepresented Students: A Systematic Review. [PDF]

Cureus
Jaganathan N, Guntaka R, Goel V, Odo N, Sun Z, Arthur ME.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source