Results 221 to 230 of about 11,305,813 (341)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Defining the scope of point-of-care ultrasound in internal medicine: a consensus statement by the point-of-care special interest group of the Internal Medicine Society of Australia and New Zealand. [PDF]

Intern Med J
Cid-Serra X, Gibbs H, Szecket N, Comeau D, Elliott P, Duong V, Perera P, Thorson P, O'Donovan R, Maguire G, Hean RV, Potter E.   +11 more
europepmc   +1 more source

Strengthening international patient advocacy perspectives on patient involvement in HTA within the HTAi Patient and Citizen Involvement Interest Group – Commentary [PDF]

, 2017
Anna Mae Scott, Janet L. Wale, Neil Bertelsen, Nick Meade, null null   +4 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society. [PDF]

Neurol Sci
Devigili G, Di Stefano G, Donadio V, Frattale I, Grazzi L, Mantovani E, Nolano M, Provitera V, Quitadamo SG, Tamburin S, Truini A, Valeriani M, Furia A, Vecchio E, Fischetti F, Greco G, Telesca A, de Tommaso M, On behhalf of neuropathic pain special interest group of the Italian neurological society (sin).   +18 more
europepmc   +1 more source

Syncretism: Politics and Interest Groups in Japan’s Financial Reforms

, 2014
Kay Shimizu, Kenji E. Kushida
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Falls prevention in community-dwelling older adults and implementation of world falls guidelines: a call for action across Europe by the European Geriatric Medicine Society Special Interest Group on Falls and Fractures. [PDF]

Eur Geriatr Med
van der Velde N, Seppala LJ, Herrero AC, Annweiler C, Jónsdóttir AB, Blain H, Dionyssiotis Y, Duque S, Frith J, Francis BN, Grodzicki T, Hay A, Hernández-Sánchez LA, Jaatinen R, Kadane CJ, Kolsek M, Kostka T, McGarrigle L, Perkisas S, Pertinatsch C, Pettersson B, Reginster JY, Ruggiero C, Sahota O, Sibille FX, Sokhal BS, Skelton DA, Spildooren J, Stanmore E, Vankova H, Vlaeyen E, Ozturk Y, Yilmaz O, Todd C, Trevisan C, Willems H, Montero-Odasso M, Martin FC, Ryg J, Masud T, European Geriatric Medicine Society Special Interest Group on Falls, Fractures.   +41 more
europepmc   +1 more source

The Role of Non -State Actors in Foreign Policy: Impact of Interest Group in Algeria on Morocco's Leaving OAU

, 2019
Jamal Laadam
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source