Results 141 to 150 of about 1,430,771 (388)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Currency Total Return Swaps: Valuation and Risk Factor Analysis [PDF]

Currency total return swaps (CTRS) are hybrid derivatives instruments that allow to simultaneously hedge against credit and currency risks. We develop a structural credit risk model to evaluate CTRS premia.
Georges Hübner, Pascal François, Romain Cuchet   +2 more
core  

Asas Keadilan Dalam Transaksi Derivatif (Khusus Yang Diperdagangkan Dalam Bursa) Sebagai Objek Pengenaan Pajak Penghasilan [PDF]

, 2012
Basically derivative transactions carried out for the divertion of risks that may arise,either the exchange rate risk, interest rate and stock price fluctuations. Derivativetransactions is then evolved rapidly.
Kadarukmi, M. E. (M)
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Analysis of fractionalized Brinkman flow in the presence of diffusion effect

Scientific Reports
A vertical plate experiences a dynamic flow of fractionalized Brinkman fluid governed by fluctuating magnetic forces. This study considers heat absorption and diffusion-thermo effects. The novelty of model is the fractionalized Fourier’s and Fick’s laws.
Shajar Abbas, Muhammad Ramzan, Inamullah Inam, Salman Saleem, Mudassar Nazar, Dilsora Abduvalieva, Hakim AL Garalleh   +6 more
doaj   +1 more source

Banks and Derivatives [PDF]

In the last ten to fifteen years financial derivative securities have become an important, and controversial, product for commercial banks. The controversy concerns whether the size, complexity, and risks associated with these securities, the ...
Gary Gorton, Richard Rosen
core  

Interest rate derivative markets in Hungary between 2009 and 2012 in light of the K14 dataset [PDF]

, 2013
MNB has received daily, transaction-level data on key Hungarian interest rate derivatives markets since the beginning of 2009 with the launching of the K14 report.
Csávás, Csaba, Kocsis, Zalán, Mák, István, Pulai, György   +3 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

INSTRUMEN DERIVATIF: PENGENALAN DALAM STRATEGI MANAJEMEN RISIKO PERUSAHAAN

Jurnal Akuntansi dan Keuangan, 2000
Recent investment inflows through the capital and money market has begun to stimulate the Indonesian economy. New investment instruments are offered by the capital market for the purpose of accomodating investor's risk dan return preferences.
Lisa Linawati Utomo
doaj