Results 81 to 90 of about 12,016 (264)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Impact of Sanctions on Industry Indices
Финансы: теория и практикаAnti-Russian sanctions have an additional impact on Russian companies. Due to the rapid change in the situation and the development of information situations, it is becoming difficult for investors to make investment decisions.
E. A. Fedorova, A. R. Nevredinov
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Finance, Accounting and Business AnalysisPurpose: This research study investigates how macroeconomic factors, such as short-term and long-term interest rates, the real exchange rate, and GDP growth, influence the pricing and volatility of agricultural derivatives, specifically focusing on white
Tanganedzani Mudau, Daniel Mokatsanyane
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The impact of exchange traded funds in freight market volatility
Journal of Shipping and TradeExchange Traded Funds (ETFs) are investment funds traded on stock exchanges that hold financial assets such as commodities, stocks, bonds, currencies, futures contracts, or debt.
Kelly Gerakoudi +2 more
doaj +1 more source
Environmental ChallengesWetlands (covering about 1.5–1.6 billion hectares globally), are critical biodiversity and livelihood hotspots. Wetlands further replenish the global economy with $47.4 trillion/year worth of ecosystem services.
Baker Matovu +10 more
doaj +1 more source