Results 151 to 160 of about 8,797,551 (312)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Nearest-Neighbor Forecasts of U.S Interest Rates

The International Journal of Banking and Finance, 2003
We employ a nonlinear, nonparametric method to model the stochastic behavior of changes in several short and long term U.S interest rates. We apply a nonlinear autoregression to the series using the locally weighted regression (LWR) estimation method, a
John Barkoulas, Christopher F. Baum, Atreya Chakraborty   +2 more
doaj  

Interest Rates and Backward-Bending Investment [PDF]

This paper studies the effect of interest rates on investment in an environment where firms make irreversible investments and learn over time. In this setting, changes in the interest rate affect both the cost of capital and the cost of delaying ...
Raj Chetty
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Monetary Policy and the Term Structure of Interest Rates When Short-Term Rates Are Close to Zero [PDF]

The zero lower bound on nominal interest rates can affect the effectiveness of monetary policy potentially in two ways. First, it limits the size of a change in the policy interest rate when trying to loosen money. For example, when the nominal rate is 0.
Shigeru Iwata
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The term structure of interest rates and inflation uncertainty [PDF]

Interest rates ; Inflation (Finance)
Rose McElhattan
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Macroeconomic challenges for Brazil post-covid-19

Revista Economia Política do Desenvolvimento
The objective of this article is to comprehensively investigate the adverse effects resulting from the persistent high interest rate policy in Brazil over many years.
Reynaldo Rubem Ferreira Jr
doaj   +2 more sources

Some key empirical determinants of short-term nominal interest rates [PDF]

Interest ...
Yash P. Mehra
core