Results 221 to 230 of about 177,179,499 (297)

Toward the harmonization of bioequivalence guidelines in Europe: Commentary on the state of the art and future priorities under ICH M13A for immediate‐release oral forms

British Journal of Clinical Pharmacology, EarlyView.
Domenico Nocera, Giusi Forastiero, Andrea Logreco, Alessia Proietti, Antonio Galluccio, Carlotta Lunghi, Elisabetta Poluzzi, Fabrizio De Ponti   +7 more
wiley   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Critical misalignments in climate pledges reveal imbalanced sustainable development pathways. [PDF]

Nat Commun
Larosa F, Rhomrassi LA, Hoyas S, Conejero JA, Garcia-Martinez J, Mallor F, Nerini FF, Vinuesa R.   +7 more
europepmc   +1 more source

Medicines, misinformation and machines: Navigating infodemics in the generative AI era

British Journal of Clinical Pharmacology, EarlyView.
Health information is now widely accessed through smartphones, online searches and increasingly through generative artificial intelligence (AI). These systems create new opportunities for communication, and in some routine contexts, well‐governed AI assistants could reduce exposure to lower quality sources by providing cautious, evidence‐aligned ...
Natansh D. Modi, Lisa M. Kalisch Ellett, Michael D. Wiese, Ashley M. Hopkins   +3 more
wiley   +1 more source

Experimental violation of a Bell-like inequality for causal order. [PDF]

Sci Adv
Guo Y, Tang H, Wang BX, Lv MY, Fan JW, Hu XM, Huang YF, Li CF, Guo GC, Chiribella G, Liu BH.   +10 more
europepmc   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

A computational model of spatial politics: Hotelling-downs model as statistical physics. [PDF]

PLoS One
Campbell C, Ackland GJ.
europepmc   +1 more source

Introduction. [PDF]

Aliment Pharmacol Ther
Howden CW.
europepmc   +1 more source

Governance of corporate misconduct through employee whistleblowing: a tripartite evolutionary game analysis. [PDF]

BMC Psychol
Ding M, Bai Y, Wang C.
europepmc   +1 more source

The internal democracy of the crisis parties in Western Europe: a quantitative analysis of the role of digitalization, ideology and populism. [PDF]

Open Res Eur
Bronet J, Borge R.
europepmc   +1 more source