Results 121 to 130 of about 6,264,854 (417)
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
, 2003 As the School of Information Sciences begins its second year as a part of the College of Communication and Information, we continue to experience change, but perhaps not as much as we once expected. The planning we undertook to prepare for our transition
School of Information Sciences
core +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Modal Interface Automata [PDF]
, 2012 De Alfaro and Henzinger's Interface Automata (IA) and Nyman et al.'s recent combination IOMTS of IA and Larsen's Modal Transition Systems (MTS) are established frameworks for specifying interfaces of system components.
G. Lüttgen +10 more
core +2 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Fourier-transform spatial modulation spectroscopy of single gold nanorods
Nanophotonics, 2018 Sensing the scattered fields of single metallic nanostructures is a crucial step towards the applications of isolated plasmonic antennas, such as for the sensing of single molecules or nanoparticles.
Kollmann Heiko +7 more
doaj +1 more source
ACPYPE - AnteChamber PYthon Parser interfacE
BMC Research Notes, 2012 BackgroundACPYPE (or AnteChamber PYthon Parser interfacE) is a wrapper script around the ANTECHAMBER software that simplifies the generation of small molecule topologies and parameters for a variety of molecular dynamics programmes like GROMACS, CHARMM ...
Alan W. Sousa da Silva, W. Vranken
semanticscholar +1 more source
, 2002 Academic 2001-2002 has just ended, so it seems a good time to recap some of the events of this year for our alumni. Importantly, our accreditation program presentation and visit went well, and we are grateful for all the support from you.
School of Information Sciences
core +1 more source
Massive ontology interface [PDF]
, 2013 This paper describes the Massive Ontology Interface (MOI), a web portal which facilitates interaction with a large ontology (over 200,000 concepts and 1.6M assertions) that is built automatically using OpenCyc as a backbone.
Legg, Catherine +2 more
core +2 more sources
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source