Results 51 to 60 of about 851,846 (204)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Evaluation of Socioeconomic Dynamics and Their Impact on Life Expectancy in Coal Mining Communities in Colombia

Mining
The study evaluates the socioeconomic dynamics and their impact on life expectancy in coal mining communities in Colombia, aligning with the Sustainable Development Goals (SDGs), assessing the relationship between production, occupation, accident rates ...
Nayive Nieves Pimiento, Edwin Rivas Trujillo, Juan M. Menéndez Aguado   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Reduction of noise and interference by rational selection of electronic components in lumped parameter channels at high speed data processing

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2019
When designing most electronic systems, the main focus is on the development of the devices themselves, while the problem of meeting the requirements for the interference protection usually take second place, which calls for a need in this particular ...
Oleksandr Tynynyka
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The hemolysis index as a tool for monitoring mild hemolysis in biochemical assays at the emergency laboratory

Journal of Biological Research
Hemolysis is a common pre-analytical error that can affect the accuracy of biochemical assay results. The aim of the study is to investigate the impact of hemolysis on the measurement of nine emergency biochemical parameters: glucose, creatinine ...
Sofiane Bouazza, Amine Bouarfa, ali khalfa, Slimane Brikhou, Abbassia Demmouche   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Competitividade relativa entre cultivares de arroz irrigado e biótipo de arroz-vermelho Relative competitivity among flooded rice cultivars and a red rice biotype

Planta Daninha, 2008
O objetivo deste trabalho foi comparar as habilidades competitivas relativas entre dois cultivares de arroz e um biótipo de arroz-vermelho. Para isso, foram realizados experimentos em casa de vegetação na Universidade Federal do Rio Grande do Sul, na ...
N.G. Fleck, D. Agostinetto, L. Galon, C.E. Schaedler   +3 more
doaj   +1 more source