Results 111 to 120 of about 4,443,290 (333)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Formation and processing of phase-shift keyed signal with pseudorandom frequency hopping in anti-interference communication systems

, 2006
Предложены методы повышения помехозащищенности приема в системах передачи цифро- вой информации за счет использования фазоманипулированных сигналов с межбитовой псевдослучайной перестройкой рабочей частоты, а также адаптивных компенсаторов ...
Чердынцев, В. А., Дубровский, В. В., Далабаев, С.   +2 more
core  

Optimisation of wireless communication system by exploitation of channel diversity [PDF]

, 2009
Communication systems are susceptible to degradation in performance because of interference received through their side lobes. The interference may be deliberate electronic counter measure (ECM), Accidental RF Interference (RFI) or natural noise.
Iqbal, Khalid
core   +2 more sources

A Method of Interference Suppression in Integrated OTFS Communication and Sensing Systems

IEEE Access
The orthogonal time-frequency space (OTFS) modulation is resistant to double selective fading, making it a promising modulation scheme for next-generation integrated sensing and communication (ISAC) systems.
Zhiling Tang, Long Yu
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Enhanced transceiver performance through self-interference cancellation in multiple modalities

, 2019
Interference in front end transceivers directly impact system performance by saturating receiver circuitry and generating non-linearities. While proper shielding can effectively eliminate external interference, self-interference continues to limit the ...
Nguyen, Thien-An Ngoc
core   +1 more source

Research on Packet Loss Caused by EMC Interference in Train Network Control System

机车电传动, 2017
EMI on the train will cause random interference to the communication of the train network control system, and then cause the packet loss of the network communication.
LI Changxian, LIN Yuwen, LI Tingxu, LI Zongliang   +3 more
doaj  

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Collaborative Search Algorithm for Multi-UAVs Under Interference Conditions: A Multi-Agent Deep Reinforcement Learning Approach

Unmanned aerial vehicles (UAVs) have emerged as a promising solution for collaborative search missions in complex environments. However, in the presence of interference, communication disruptions between UAVs and ground control stations can severely ...
Yu Zhang, Wei Wang, Yihang Du, Yong Chen
core   +1 more source