Results 151 to 160 of about 303,375 (325)
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
Angewandte Chemie, EarlyView.We report “Sirtuin Trapping Ligands” (SirTraps), mechanism‐based 1,2,3‐triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP‐ribose (ADPR) adducts from NAD+. These trapped intermediates stall the enzyme in an inactive state, providing a biocompatible alternative to thiocarbonyl inhibitors and a blueprint ...
Florian Friedrich +16 more
wiley +2 more sources
Advanced Science, EarlyView.A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong +15 more
wiley +1 more source
Permanent scatterers in SAR interferometry
IEEE 1999 International Geoscience and Remote Sensing Symposium. IGARSS'99 (Cat. No.99CH36293), 1999 A. Ferretti, C. Prati, F. Rocca
semanticscholar +1 more source
Advanced Science, EarlyView.The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source
Advanced Science, EarlyView.This work breaks conventional design paradigms by leveraging a polarization‐multiplexed metasurface to create the first chromatic confocal sensor with dynamically switchable measurement performance, achieving 10‐fold miniaturization (Ø1 mm vs cm‐scale conventional probes).
Zhicheng Zhao +5 more
wiley +1 more source
From Complex Shaping to Mirror Finish: Additive Manufacturing of Aerospace‐grade Cf/SiC Space Optics
Advanced Science, EarlyView.An integrated additive manufacturing route combines selective laser sintering, engineered interphases, and optimized silicon infiltration to fabricate complex Cf/SiC composites. The approach enables precise shaping, high mechanical performance, and excellent optical reflectivity, offering a scalable solution for advanced aerospace optics with both ...
Buhao Zhang +8 more
wiley +1 more source
Seismic and electromagnetic controlled‐source interferometry in dissipative media [PDF]
, 2008 Kees Wapenaar, Evert Slob, Roel Snieder
openalex +1 more source
Advanced Science, EarlyView.Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang +27 more
wiley +1 more source
Phase and contrast moiré signatures in two-dimensional cone beam interferometry [PDF]
, 2023 D. Sarenac +15 more
openalex +1 more source