Results 271 to 280 of about 303,375 (325)
Opportunities of patient‐derived organoids in drug development
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley +1 more source
Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP. [PDF]
Manage MM, Nix JC, Page RC.
europepmc +1 more source
The scaffold protein GKAP and the hub protein LC8 form a well‐defined hexameric complex, with the stoichiometry of 2 GKAP : 2 LC8 dimers. NMR and molecular dynamics calculations confirm that the LC8‐binding segment of GKAP is intrinsically disordered even in the complex form.
Eszter Nagy‐Kanta +10 more
wiley +1 more source
Drop Friction on Textured Lubricant-Coated Surfaces. [PDF]
Chen X +6 more
europepmc +1 more source
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen +7 more
wiley +1 more source
Electrically tunable quantum interference of atomic spins on surfaces. [PDF]
Wang H +11 more
europepmc +1 more source
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andrea J. Pinto +9 more
wiley +1 more source

